智能体技术在病理诊断流程中的应用进展

Applications of Intelligent Agents in the Pathology Diagnostic Workflow

  • 摘要: 随人工智能技术的飞速发展,计算病理已从面向单一任务的模型,发展至支持多器官、多病种、多任务的基础模型范式,但现有方法仍局限于单次图像推断,难以完整模拟真实临床场景中的综合诊断过程。近年来,大语言模型推动了智能体(agent)范式的发展,其通过导航、推理、工具调用等机制,为建模复杂诊断流程提供了新思路。本文从临床病理诊断流程出发,系统梳理了病理诊断在低倍概览、诊断分析及报告撰写三个阶段中的关键难点及计算病理研究的进展,并讨论了智能体相关技术当前在各阶段中的功能定位与实现方式。尽管现有研究的验证场景仍有限,但构建病理诊断智能体系统所需的核心模块与方法已基本具备,智能体相关技术有望助力构建真正适用于临床的病理智能辅助诊疗平台。

     

    Abstract: With the rapid advancement of artificial intelligence technology, computational pathology has evolved from task-specific models to foundation models capable of supporting multiple organs, diseases, and downstream tasks. However, existing methods remain limited to single-pass inference on images and are unable to fully emulate the complex diagnostic processes encountered in real-world clinical settings. In recent years, large language models have driven the development of agent-based paradigms. By leveraging capabilities such as navigation, reasoning, and tool use, these frameworks offer a novel approach for modeling complex diagnostic workflows. Framed within the context of clinical pathology diagnostic processes, this article systematically reviews the key challenges and advances in computational pathology research across three stages: preliminary overview, diagnostic analysis, and report writing, and discusses the current functional roles and implementation approaches of agent-based technologies at each stage. Although validation scenarios in existing studies remain limited, the core modules and methods required to construct a pathology diagnostic agent system are largely in place. Agent-related technologies are expected to facilitate the development of a clinically deployable intelligent assistance platform for pathology diagnosis.

     

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