• 摘要: 抗中性粒细胞胞浆抗体相关肾小球肾炎(anti-neutrophil cytoplasmic antibody-associated glomerulonephritis, AAGN)在老年患者中临床表现隐匿, 易延误诊断, 合并症多, 治疗相关并发症发生率高, 预后差, 是导致急性肾损伤和终末期肾病的重要病因。本指南由多学科专家制订, 涵盖治疗原则、诱导缓解与维持缓解治疗、复发及难治性疾病处理、肾脏替代治疗, 以及合并症与并发症管理等内容, 旨在为老年AAGN患者提供个体化诊疗意见, 改善临床预后。

     

    Abstract: Anti-neutrophil cytoplasmic antibody-associated glomerulonephritis (AAGN) often presents with clinically insidious features in elderly patients, leading to delayed diagnosis. It is frequently accompanied by multiple comorbidities, a high incidence of treatment-related complications, and poor prognosis, making it a significant cause of acute kidney injury and end-stage renal disease. This guideline, developed by a multidisciplinary expert panel, covers treatment principles, induction and maintenance of remission, management of relapsing and refractory diseases, renal replacement therapy, as well as the management of comorbidities and complications. It aims to provide an individualized diagnostic and therapeutic consensus for elderly patients with AAGN and to improve clinical outcomes.

     

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