运动储备在帕金森病患者中的研究进展

Research Progress on Motor Reserve in Patients with Parkinson's Disease

  • 摘要: 在帕金森病(Parkinson's disease,PD)的临床管理中,延缓运动功能衰退是一项关键挑战。“运动储备”(motor reserve)概念的提出,为解释PD患者运动功能衰退的个体异质性及制订防治策略提供了新视角。运动储备是指大脑通过神经可塑性改变、功能重组及代偿机制以应对神经退行性病变的能力。较高水平的运动储备可有效延缓PD的发生与进展。本文系统梳理了运动储备在PD患者中的研究现状,包括其概念起源与发展、作用机制、评估工具,并探讨了PD相关神经影像学标志物、影响因素及干预策略,以期为未来开发针对PD及其他运动障碍疾病的精准评估与干预方案提供参考与借鉴。

     

    Abstract: In the clinical management of Parkinson's disease (PD), delaying motor decline remains a key challenge. The concept of motor reserve provides a novel perspective for explaining the individual heterogeneity in motor deterioration among PD patients and for developing prevention strategies. Motor reserve refers to the brain's capacity to cope with neurodegenerative pathology through mechanisms of neural plasticity, functional reorganization, and compensation. A higher level of motor reserve can effectively delay the onset and progression of PD. This review synthesizes the current state of research on motor reserve in PD patients, including the conceptual origin and development of motor reserve, its underlying mechanisms, and assessment tools. It further explores neuroimaging biomarkers related to motor reserve in PD, its influencing factors, and potential intervention strategies. This review aims to provide insights for the future development of precise assessment and intervention strategies for PD and other motor disorders.

     

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