Abstract:
In the clinical management of Parkinson's disease (PD), delaying motor decline remains a key challenge. The concept of motor reserve provides a novel perspective for explaining the individual heterogeneity in motor deterioration among PD patients and for developing prevention strategies. Motor reserve refers to the brain's capacity to cope with neurodegenerative pathology through mechanisms of neural plasticity, functional reorganization, and compensation. A higher level of motor reserve can effectively delay the onset and progression of PD. This review synthesizes the current state of research on motor reserve in PD patients, including the conceptual origin and development of motor reserve, its underlying mechanisms, and assessment tools. It further explores neuroimaging biomarkers related to motor reserve in PD, its influencing factors, and potential intervention strategies. This review aims to provide insights for the future development of precise assessment and intervention strategies for PD and other motor disorders.