Abstract: In recent years, the global prevalence of diabetes has shown a continuous upward trend, leading to an increasingly heavy disease burden. Poorly controlled diabetes and its complications not only significantly reduce patients' quality of life but may also be life-threatening, while simultaneously posing severe challenges to socioeconomic development. In December 2024, based on the latest evidence-based medical findings, the American Diabetes Association (ADA) released the 2025 American Diabetes Association Standards of Care in Diabetes, which provide comprehensive updates to the integrated management strategies for diabetes, its complications, and comorbidities. This article interprets the key elements of these guidelines, aiming to offer the latest evidence-based references and practical guidance for the clinical diagnosis and treatment of diabetes.