新发突发呼吸道传染性病原微生物分级检测专家共识(2024)

Expert Consensus on Tiered Detection of Newly Emerging and Outbreak Respiratory Infectious Pathogens (2024)

  • 摘要: 近年来, 呼吸道传染性疾病不断暴发流行, 给全球公共卫生和医疗卫生体系带来了巨大挑战。如何及时采取分级筛查和检测策略, 系统覆盖引起呼吸道急性感染的临床常见传染性病原体、慢性感染或少见呼吸道传染性病原体, 着眼可能的新发突发呼吸道传染性病原体, 快速明确致病微生物, 成为临床诊断亟需解决的问题。为此, 中国医院协会临床微生物实验室专业委员会组织多学科专家, 总结目前国内实验室检测在临床实践中所积累的应用经验, 结合当前国际最新研究进展, 共同编写了《新发突发呼吸道传染性病原微生物分级检测专家共识(2024)》。本共识通过分析重大新发突发呼吸道病原体传染性和感染特点, 兼顾患者人群特征, 制定了包含传统微生物形态学、培养、免疫学、分子生物学以及宏基因组测序等方法的三级检测策略, 明确了在不同阶段针对的目标病原体及推荐检测方法, 为提高新发突发呼吸道传染病的诊断能力提供了指导建议和参考依据。

     

    Abstract: In recent years, respiratory infectious disease outbreaks have been continually emerging internationally, posing significant challenges to global public health and healthcare systems. How to promptly implement a tiered screening and detection strategy that systematically covers common clinical infectious pathogens causing acute respiratory infections, pathogens causing chronic respiratory infections, and rare respiratory infectious pathogens, while focusing on potential newly emerging respiratory infectious pathogens, and quickly identifying the causative microorganisms, has become a critical issue in clinical diagnosis. To address this issue, the Chinese Hospital Association Clinical Microbiology Laboratory Specialized Committee assembled a multidisciplinary group of experts to summarize the practical experience accumulated in domestic laboratory testing.Incombination with the latest international research progress, they developed the Expert Consensus on Tiered Detection of Newly Emerging and Outbreak Respiratory Infectious Pathogens (2024). This consensus analyzes the major characteristics of newly emerging and outbreak respiratory infections, considers patient population characteristics, and proposes a three-tiered detection strategy that includes traditional microbiological morphology, culture, immunology, molecular biology, and metagenomic sequencing methods. It defines the target pathogens and recommends detection methods at different stages, providing guidance and reference for improving the diagnostic capacity for newly emerging and outbreak respiratory infectious diseases.

     

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