摘要:
目的 了解口腔微生物与消化系统疾病的研究现状、热点和前沿。方法 选择Web of Science核心合集数据库，以口腔微生物和消化系统疾病为主题进行检索，采用VOSviewer、CiteSpace和R语言中的“bibliometrix”软件包进行信息挖掘与梳理。结果 共纳入1228篇有效文献。从发文趋势看，未来口腔微生物与消化系统疾病的相关性研究将持续成为国内外研究热点；发文机构以高校为主导，机构分布集中且以团队合作为主，但总体合作网络较为松散；从地区分布看，美国是该领域研究的核心力量，中国、英国次之；在国际合作中，中美两国合作密切，但中国与其他国家或地区的合作广度仍显不足；当前研究热点聚焦于口腔菌群与肠道菌群、炎症性肠病以及消化系统肿瘤之间的紧密联系。结论 口腔微生物与消化系统疾病相关领域研究呈现高度活跃和多元化特点。口腔菌群与肠道菌群、炎症性肠病以及消化系统肿瘤（特别是食管癌、胃癌、胰腺癌、结直肠癌）的相关性研究仍是热门领域，后续学者可进一步深入探究其具体作用机制，并在生物标志物的发现和应用方面寻找创新点。然而，不同研究机构之间的合作与交流尚显不足，这在一定程度上制约了资源的共享与利用。
Abstract:
Objective To investigate the current research landscape, hotspots, and frontiers in the relationship between oral microbiota and digestive system diseases. Methods A comprehensive search was conducted using the Web of Science Core Collection database with the themes of "oral microbiota" and "digestive system diseases." Data mining and analysis were performed using VOSviewer, CiteSpace, and the "bibliometrix" package in R. Results A total of 1,228 eligible articles were included. Analysis revealed that research on the correlation between oral microbiota and digestive system diseases will remain a global hotspot. Academic institutions dominated the publications, with centralized institutional distribution and team-based collaboration, though overall collaboration networks remained fragmented. Geographically, the United States emerged as the leading contributor, followed by China and the United Kingdom. While China-U.S. collaborations were prominent, China’s engagement with other regions remained limited. Current research hotspots focus on the interplay between oral microbiota and gut microbiota, inflammatory bowel disease (IBD), and digestive system tumors. Conclusions Research in this field demonstrates high activity and diversity. Studies on the associations of oral microbiota with gut microbiota, IBD, and digestive system tumors (particularly esophageal, gastric, pancreatic, and colorectal cancers) remain prominent. Future studies should prioritize elucidating underlying mechanisms and innovating in biomarker discovery and application. However, insufficient collaboration and resource-sharing among institutions currently hinder progress in this field.
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