Abstract: Objective To explore the construction, implementation, and operational effectiveness of an integrated Doctor-Nurse integration model for breast cancer chemotherapy outpatients, and to provide a reference for the standardized management of breast cancer chemotherapy patients. Methods In 2019, the Breast Surgery Department of Peking Union Medical College Hospital set up a medical and nursing integrated team to build a whole process management path including chemotherapy preparation period, chemotherapy period, and chemotherapy interval, and established a whole process appointment, time based treatment, and closed-loop management of patients in breast cancer chemotherapy clinic. We compared medical efficiency indicators, chemotherapy safety indicators, staffing ratios in the chemotherapy outpatient department, and satisfaction levels of patients and medical staff before (2018) and after (2019) the implementation of this model to evaluate its effectiveness. Results Before the implementation of the model, the average waiting time for patients was 30– 120 minutes (75.40±20.97 min), the annual chemotherapy volume in the outpatient department was 8,715 patient-visits, and two ward nurses were required daily to support the chemotherapy outpatient department. After the implementation of the model, patients were able to receive chemotherapy directly upon arrival at the hospital according to their scheduled time slots without waiting. The annual chemotherapy volume increased to 10,101 patient-visits. The two chemotherapy units could flexibly adjust staffing according to time slots. Ward chemotherapy nurses transitioned from an on-call status to a reserve status. The incidence rates of nursing adverse events, catheterrelated adverse events, and chemotherapy-related adverse reactions remained at 0%, consistent with the pre-implementation period. Compared with the pre-implementation period, the satisfaction scores of patients and medical staff in all dimensions and the total scores significantly increased after the implementation of the model, with statistically significant differences (P<0.05 for all). Conclusion The integrated doctornurse management model for breast cancer chemotherapy outpatients, after construction and practical verification, has been shown to effectively enhance medical service efficiency, ensure chemotherapy safety, optimize the allocation of human resources, and improve the satisfaction of both medical staff and patients.