Pituitary Research Through Rat Models—Liu Shih-Hao’s Studying in London and FarReaching Influence
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摘要: 我国内分泌学科奠基人刘士豪,于20世纪30年代末在英国进修时,用大鼠作为研究对象探究下丘脑—垂体—性腺轴的调控。此点尚未蒙前人措意,故本文拟简介该系列研究的基本情况,并将这一系列较为微观的医学史事件,放置于刘士豪个人以及当时内分泌学研究历史的大背景下,对其进行较为宏观的考察;同时,将此系列研究与20余年后刘士豪所作的《内分泌研究发展的方向》报告勾连起来,发掘其背后隐藏的联系,从而揭示该系列研究丰富的医学史意义,以期能够进一步补充和呈现出刘士豪个人学术史乃至我国内分泌学科的创建与发展史。
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关键词:
- 刘士豪 /
- 垂体 /
- 动物模型 /
- 下丘脑—垂体—性腺轴
Abstract: Liu Shih-Hao, the founder of endocrinology in China, used rats as research objects to conduct experimental research on the regulation of the hypothalamic-pituitary-gonadal axis when he was studying in the UK in the late 1930s. This point has not been received enough attention, so this paper intends to introduce the basic situation of this series of studies, and place this series of relatively micro medical history events in Liu Shih-Hao's personal academic history and the research situation of endocrinology at that time, as well as the larger social and historical background, to conduct a relatively macro investigation. Then, by linking and exploring the pituitary hormone series research with Liu Shih-Hao's report "The Direction of Endocrine Research Development" made more than 20 years later, these two historical events that are far apart, to reveal the rich medical historical significance of the series research. In order to further supplement and present Liu Shih-Hao's personal academic history and even the establishment and development history of endocrinology in China.-
Keywords:
- Liu Shihao /
- pituitary /
- animal model /
- hypothalamic-pituitary-gonadal axis
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[1] 李乃适.刘士豪、朱宪彝与第一个由中国人命名的疾病--肾性骨营养不良[J].中华骨质疏松和骨矿盐疾病杂志, 2008, 1(01):78-80. [2] 李乃适,夏维波,周学瀛.从ROD到CKD-MBD?肾性骨营养不良疾病命名的历史沿革[J].中华骨质疏松和骨矿盐疾病杂志, 2021, 14(01):4-8. [3] Li N. Liu Shih-Hao:pioneer of translational medicine in China. Sci China Life Sci. 2011, 54(12):1089-95.
[4] Liu S.H., Noble R.L. The effects of extracts of pregnant mare serum and human pregnant urine on the reproductive system of hypophysectomized male rats[J]. Journal of Endocrinology, 1939, 1:14.
[5] Liu S.H., Noble R.L. The effects of extracts of pregnant mare serum and human pregnant urine on the reproductive system of hypophysectomized female rats[J]. Journal of Endocrinology, 1939, 1:20-21.
[6] 刘士豪档案.中国医学科学院档案中心. [7] Dodds EC, LiuSH, Noble RL.Water balance and blood changes following posterior pituitary extract administration[J].J Physiol, 1938, 94:124-35.
[8] Liu S.H., Noble R.L. Renal insufficiency following intra-renal arterial injection of posterior pituitary pressor principles[J]. J Physiol, 1938, 93:13.
[9] Liu S.H. Pathological states produced by the administration of posterior pituitary pressor principal[J]. Chin Med J,1939, 55:448.
[10] Meamber D.L., Fraenkel-Conrat H.L., Evans H.M. et al. The preparation of pituitary growth hormone free from lactogenic and thyrotropic hormones[J]. Science, 1939, 90:19-20.
[11] Evans B., Jones E. Organ extracts and the development of psychiatry:hormonal treatments at the Maudsley hospital 1923-1938[J]. Journal of the History of the Behavioral Sciences, 2012, 48(3):257-269.
[12] Dickens F. Edward Charles Dodds, 13 October 1899--16 December 1973. Biogr Mem Fellows R Soc. 1975;21:227-67. doi: 10.1098/rsbm.1975.0006.
[13] Edward Charles Dodds. Lancet. 1973, 29;2(7844):1506-7.
[14] Greep R.O.. The Effect of Gonadotropic Hormones on the Persisting Corpora Lutea in Hypophysectomized Rats[J], Endocrinology 1938, 23:154-163
[15] Sendroy J.Jr, Liu S.H. Gasometric determination of oxygen and carbon monoxide in blood[J]. Journal of Biological Chemistry, 1930, 89:133-152.
[16] Van Slyke D.D., Sendroy J.Jr., Liu S.H. Manometric analysis of gas mixtures:II. Carbon dioxide by the isolation method[J]. Journal of Biological Chemistry, 1932, 95:531-546.
[17] Van Slyke D.D., Sendroy J.Jr., Liu S.H. Manometric analysis of gas mixtures:III. Manometric determination of carbon dioxide tension and pHs of blood[J]. Journal of Biological Chemistry, 1932, 95:547-568.
[18] 李乃适.第六编英伦进阶·导语[A].李乃适主编.刘士豪论文选集[C].北京:中国协和医科大学出版社, 2020:323. [19] 刘士豪.内分泌研究发展的方向[J].国外医学动态, 1964, 10:570. [20] 李乃适整理.金自孟教授访谈录[A].李乃适主编.刘士豪论文选集[C].北京:中国协和医科大学出版社, 2020:463-465.
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