Abstract: Recent studies have shown that human health and susceptibility to various diseases are closely related to microorganisms. For example, in women of childbearing age, changes in the reproductive tract microbiota are associated with various pregnancy outcomes. Traditional concepts suggest that tubal pregnancy is related to tubal inflammation, development, functional abnormalities, and surgical procedures. With the deepening of research on microbial, it has been found that changes in the reproductive tract microbiota, such as the imbalance of vaginal flora can affect the receptivity of the endometrium, thereby increasing the rate of tubal pregnancy. This article reviews the literature to summarize the research progress on the correlation between reproductive tract microbiota and tubal pregnancy, in order to explore the potential pathogenesis of tubal pregnancy and provide valuable references for more in-depth clinical research.