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Obstructive Sleep Apnea-induced Gut Dysbiosis and Ischaemic Stroke: Mechanism and Research Progress
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摘要: 缺血性脑卒中作为一种高发病率、高死亡率、高致残率、高复发率的脑血管疾病，是导致我国中老年人残疾和死亡的重要原因。因此，识别与缺血性脑卒中相关危险因素并进行有效预防至关重要。有研究表明，阻塞性睡眠呼吸暂停是缺血性脑卒中发生的独立危险因素，但具体机制尚未明确。随着新一代测序技术的发展，研究发现阻塞性睡眠呼吸暂停可引起肠道菌群改变，而肠道菌群可能与缺血性脑卒中密切相关。因此，本文就阻塞性睡眠呼吸暂停诱导肠道菌群失调与缺血性脑卒中的相关机制进行综述，以期为阐明阻塞性睡眠呼吸暂停引起缺血性脑卒中的潜在病理机制提供依据。Abstract: Ischemic stroke, a cerebrovascular disease with high incidence, high mortality, high disability rate and high recurrence rate, is an important cause of death and disability of middle-aged and elderly people in China, and imposes a huge burden to society and families. Therefore, it is essential to identify the risk factors associated with ischemic stroke and effectively prevent them. Studies have shown that obstructive sleep apnea is an independent risk factor for ischemic stroke. However, the exact pathological mechanism of their association has not been clarified. With the development of next-generation sequencing technology, more and more studies have focused on intestinal microbiota. They have found that obstructive sleep apnea can cause intestinal microbiota changes, and intestinal microbiota may be closely related to ischemic stroke. Therefore, this paper attempts to investigate the relationship between intestinal flora and ischemic stroke, so as to reveal the potential pathological mechanism of ischemic stroke caused by obstructive sleep apnea.
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作者贡献：刘苗苗负责论文撰写；岳红梅负责选题设计及论文修订；李雅亭、许金回负责文献收集；武兴东、朱浩斌负责论文修订。利益冲突：所有作者均声明不存在利益冲突
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