HMGB1在调节骨关节炎软骨细胞功能中的作用机制

Research Progress on the Role of HMGB1 in Regulating the Function of Osteoarthritis Chondrocytes

摘要: 骨关节炎(osteoarthritis，OA)是一种慢性退行性关节疾病，其主要特征是关节软骨破坏，导致患者身体疼痛和残疾，严重影响其生活质量。OA可由多种病因诱发，而关节软骨的病理改变被认为是OA发生的关键驱动因素之一。高迁移率族蛋白1(high mobility group box-1 protein，HMGB1)作为一种真核细胞内的非组蛋白，可参与调节软骨细胞炎症及凋亡过程，从而导致关节软骨受损，诱发OA。本文就HMGB1在OA软骨细胞中的作用机制进行综述，以期为临床防治OA提供新思路。

Abstract: Osteoarthritis (OA) is a chronic degenerative joint disease whose main characteristic is the destruction of articular cartilage, causing pain and disability in patients and seriously affecting their quality of life. OA can be induced by a variety of causes, and pathological changes in articular cartilage are considered to be one of the key driving factors for the occurrence of OA. High mobility group box-1 protein (HMGB1), as a non-histone protein in eukaryotic cells, can participate in regulating the inflammation and apoptosis process of OA chondrocytes, thus leading to the occurrence of OA. This article reviews the research on the mechanism of HMGB1 in OA chondrocytes, with a view to providing new ideas for the clinical prevention and treatment of OA.