Abstract: Insulin was introduced to China in 1923. Before it entered China, the Internal Medicine Department of Peking Union Medical College Hospital(PUMCH) had actively introduced insulin and planned to produce the drug in China. On the occasion of the 100th anniversary of the introduction of insulin into China, the author accessed the archives of Peking Union Medical College(PUMC), the medical journals, the annual report of PUMCH, and other historical materials to trace this little-known history. The aim is to enrich the history of medicines, the history of diabetes, and the history of the PUMC and PUMCH.