李晓燕, 徐新杰, 罗欣, 尤欣. 粪菌移植治疗孤独症谱系障碍的研究进展[J]. 协和医学杂志, 2022, 13(5): 753-759. DOI: 10.12290/xhyxzz.2022-0301
引用本文: 李晓燕, 徐新杰, 罗欣, 尤欣. 粪菌移植治疗孤独症谱系障碍的研究进展[J]. 协和医学杂志, 2022, 13(5): 753-759. DOI: 10.12290/xhyxzz.2022-0301
LI Xiaoyan, XU Xinjie, LUO Xin, YOU Xin. Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 753-759. DOI: 10.12290/xhyxzz.2022-0301
Citation: LI Xiaoyan, XU Xinjie, LUO Xin, YOU Xin. Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 753-759. DOI: 10.12290/xhyxzz.2022-0301

粪菌移植治疗孤独症谱系障碍的研究进展

Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation

  • 摘要: 孤独症谱系障碍(autism spectrum disorder,ASD) 是发病于儿童早期的神经发育障碍性疾病,目前尚无有效的治愈手段。其发病率近年来明显上升,给患者家庭和社会带来了沉重负担。ASD患者多存在胃肠道症状和肠道菌群失衡,研究发现ASD患者的胃肠道功能障碍与肠道菌群结构变化密切相关,且通过粪菌移植可显著改善ASD相关症状。本文通过总结粪菌移植治疗ASD的最新研究进展,以期为ASD的治疗提供新思路。

     

    Abstract: Autism spectrum disorder (ASD), a neurodevelopmental disorder during early childhood, currently has no effective treatment. The prevalence of ASD has been increasing, which brings a heavy burden to the family of the patients and the society. Children with ASD are accompanied by gastrointestinal symptoms and have an imbalance of intestinal microbiota. Fecal microbiota transplantation (FMT) can improve autism-related symptoms in children with ASD. This review aims to summarize the research progress of FMT for treating ASD to provide a novel strategy for this untreatable disease.

     

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