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西藏地区藏族人群胃癌组织中H3K27me3表达水平及其临床意义

Expression of H3K27me3 in Tibetan Patients with Gastric Cancer and Its Significance

    摘要
  • 摘要:
      目的  探究H3K27me3在西藏地区藏族人群胃癌组织中的表达水平及其与临床、病理特征的相关性。
      方法  回顾性收集2019年8月至2021年8月西藏自治区人民医院藏族胃癌患者及同期藏族非胃癌患者的临床与病理资料。采用免疫组化法检测胃癌患者手术切除的肿瘤组织、癌旁正常胃黏膜组织及非胃癌患者正常胃黏膜组织中H3K27me3表达情况，并比较不同临床与病理特征胃癌患者之间H3K27me3表达差异。
      结果  共入选符合纳入和排除标准的藏族胃癌患者54例，藏族非胃癌患者55例。H3K27me3定位于细胞核, 阳性表达时细胞核呈棕黄色颗粒状着色。胃癌组织中H3K27me3高表达率显著高于癌旁正常胃黏膜组织64.8%(35/54)比29.6%(16/54)，P＜0.001和非胃癌患者正常胃黏膜组织64.8%(35/54)比34.5%(19/55)，P=0.002，癌旁正常胃黏膜组织中H3K27me3高表达率与非胃癌患者正常胃黏膜组织无显著差异(P=0.683)。H3K27me3表达水平在不同年龄、性别及Lauren分型、分化程度、浸润深度、肿瘤最大径、TNM分期等胃癌患者之间均无显著差异(P均＞0.05)。
      结论  西藏地区藏族人群胃癌组织中H3K27me3表达水平显著增高，暂未发现H3K27me3表达水平与藏族胃癌患者临床及病理特征具有相关性。

     

    Abstract:
      Objective  To investigate the expression and its significance of H3K27me3 in Tibetan patients with gastric cancer.
      Methods  Clinical and pathological data were retrospectively collected from Tibetan patients with gastric cancer in the Tibet Autonomous Region People's Hospital from August 2019 to August 2021 and Tibetan non-gastric cancer patients during the same period. The expression of H3K27me3 in gastric cancer tissues, corresponding adjacent normal gastric mucosa and normal gastric mucosa of Tibetan patients with non-gastric cancer tissues was detected by immunohistochemical method, and the differences of H3K27me3 expression between gastric cancer patients with different clinical and pathological characteristics was compared.
      Results  A total of 54 Tibetan gastric cancer patients and 55 Tibetan non-gastric cancer patients who met the inclusion and exclusion criteria were enrolled. H3K27me3 was localized in the nucleus, and the nucleus showed brownish-yellow granular staining when positively expressed. The high expression rate of H3K27me3 in gastric cancer tissues was significantly higher than that in adjacent normal gastric mucosa tissue64.8%(35/54) vs. 29.6%(16/54), P < 0.001and normal gastric mucosal tissue of Tibetan patients with non-gastric cancer64.8%(35/54) vs. 34.5%(19/55), P=0.002, and the high expression rate of H3K27me3 in the adjacent normal gastric mucosa tissue was not significantly different from that in normal gastric mucosal tissue of Tibetan patients with non-gastric cancer(P=0.683). H3K27me3 expression in gastric cancer tissues was not related to gender, age, degree of differentiation, depth of invasion, maximum tumor size, Lauren's classification, lymph node metastasis, vascular and nerve invasion and TNM stage.
      Conclusions  H3K27me3 is highly expressed in gastric cancer tissues of Tibetan people in Tibet. There is no significant difference in H3K27me3 positive expression cells in adjacent tissues and normal gastric mucosa. The significance of H3K27me3 in Tibetan patients with gastric cancer is uncertain and requires further investigations.

     

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