Abstract: Infectious diseases begin and progress rapidly, so early accurate identification and detection of pathogen resistance is crucial for the prognosis of patients and the curb on drug resistance. Conventional clinical microbiological technology has been unable to meet the needs of rapid diagnosis and treatment. Therefore, rapid detection technology becomes the focus of clinic and clinical laboratory. This paper reviews the research status of the latest technology for rapid identification and detection of drug sensitivity, and discusses their problems and the key points of future development, providing reference to the introduction of new technologies in the clinical microbiological laboratory in the future.