Abstract: Perimenopause is a special period in women's life, during which both the ovarian function and the estrogen level decline progressively. Perimenopause is characterized by a remarkable increase in the risk of many metabolic disorders, including overweight/obesity, metabolic syndrome, dyslipidemia, hyperglycemic disease, musculoskeletal dysfunction, and so on. The Mediterranean diet is beneficial to reducing the risk of various metabolic diseases, which is implicational for improving the healthcare of women at perimenopause. Personalized nutritional management based on one's own metabolic feature is the cornerstone of health care for perimenopausal women.