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林奇综合征相关子宫内膜癌研究进展

刘晓,  李玉兰,  马杏,  许飞雪

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刘晓, 李玉兰, 马杏, 许飞雪. 林奇综合征相关子宫内膜癌研究进展[J]. 协和医学杂志.
引用本文: 刘晓, 李玉兰, 马杏, 许飞雪. 林奇综合征相关子宫内膜癌研究进展[J]. 协和医学杂志.
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LIU Xiao, LI Yulan, MA Xing, XU Feixue. Advances in the Study of Lynch Syndrome Associated Endometrial Cancer[J]. Medical Journal of Peking Union Medical College Hospital.
Citation: LIU Xiao, LI Yulan, MA Xing, XU Feixue. Advances in the Study of Lynch Syndrome Associated Endometrial Cancer[J]. Medical Journal of Peking Union Medical College Hospital.
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林奇综合征相关子宫内膜癌研究进展

  • 1 兰州大学第一临床医学院, 兰州 730000;

  • 2 兰州大学第一医院妇产科 甘肃省妇科肿瘤重点实验室, 兰州 730000

基金项目: 

甘肃省科技计划（21JR7RA378）

详细信息
    通讯作者:

    许飞雪,E-mail:xfx.sxq@163.com

Advances in the Study of Lynch Syndrome Associated Endometrial Cancer

  • 1 The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China;

  • 2 Department of Obstetrics and Gynecology, Gansu Provincial Key Laboratory of Gynecological Oncology, First Hospital of Lanzhou University, Lanzhou 730000, China

Funds: 

Science and technology project of Gansu Province(21JR7RA378)

    摘要
  • 摘要: 林奇综合征（Lynch syndrome,LS）是错配修复基因缺陷引起的常染色体显性遗传病，多系统恶性肿瘤易感是其主要特征，LS相关子宫内膜癌（LS associated endometrial cancer，LS-EC）是LS最常见的肠外前哨癌。精准医学时代，LS-EC的早期筛查对于预防LS相关其他恶性肿瘤的发生具有重要意义。本文就LS-EC的筛查手段及预防研究进展进行综述，以期为LS相关肿瘤患者精准诊疗及预防提供参考。
    Abstract: Lynch syndrome (LS) is an autosomal dominant genetic disorder caused by mismatch repair gene defects, and the susceptibility to multi-system malignancies is the main feature. Ls associated endometrial cancer (LS-EC) is the most common extraintestinal sentinel cancer of LS. In the era of precision medicine, the early screening of LS-EC is of great significance to prevent the occurrence of other LS related malignant tumors. This paper reviewed the research progress on screening methods and prevention of LS-EC, in order to provide reference for precise diagnosis and prevention of LS-related tumor patient.
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    • 参考文献(30)
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出版历程
  • 收稿日期:  2022-04-07
  • 网络出版日期:  2022-06-01

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