Abstract: Public health emergencies are characterized by unpredictability, sudden outbreak, complex causes, great destruction, strong harmfulness, and wide influence, which bring great challenges to nursing management. During the fight against coronavirus disease 2019, the first line experience of the nursing care team from Peking Union Medical College Hospital has shown that, The overall goal of "nursing care of high quality" and "zero infection of medical staff" could be achieved by improving rules and regulations, training all employees and staff, implementing elaborate management, and building team capacity.