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单细胞测序及其与未来脑恶性肿瘤的诊疗

王月坤 刘芃昊 王裕 马文斌

王月坤, 刘芃昊, 王裕, 马文斌. 单细胞测序及其与未来脑恶性肿瘤的诊疗[J]. 协和医学杂志, 2020, 11(5): 606-614. doi: 10.3969/j.issn.1674-9081.2020.05.018
引用本文: 王月坤, 刘芃昊, 王裕, 马文斌. 单细胞测序及其与未来脑恶性肿瘤的诊疗[J]. 协和医学杂志, 2020, 11(5): 606-614. doi: 10.3969/j.issn.1674-9081.2020.05.018
Yue-kun WANG, Peng-hao LIU, Yu WANG, Wen-bin MA. Single-cell Sequencing and Its Prospect in the Management of Brain Malignant Tumor[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(5): 606-614. doi: 10.3969/j.issn.1674-9081.2020.05.018
Citation: Yue-kun WANG, Peng-hao LIU, Yu WANG, Wen-bin MA. Single-cell Sequencing and Its Prospect in the Management of Brain Malignant Tumor[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(5): 606-614. doi: 10.3969/j.issn.1674-9081.2020.05.018

单细胞测序及其与未来脑恶性肿瘤的诊疗

doi: 10.3969/j.issn.1674-9081.2020.05.018
基金项目: 

中国医学科学院医学与健康科技创新工程 2016-I2M-2-001

详细信息
    通讯作者:

    王裕  电话:010-69152533,E-mail: ywang@pumch.cn

  • 中图分类号: R739.41

Single-cell Sequencing and Its Prospect in the Management of Brain Malignant Tumor

More Information
    Corresponding author: WANG Yu  Tel: 86-10-69152533, E-mail: ywang@pumch.cn
  • 摘要: 单细胞测序技术可对分散的单个细胞分别进行基因组、转录组、表观遗传组或多组学测序,可从较少的肿瘤细胞中获得取可能多的信息。相较于整体测序,对单细胞测序技术在肿瘤内和肿瘤间异质性的研究有助于了解肿瘤动态变化机制。利用单细胞测序技术研究脑恶性肿瘤进展过程中不同阶段的分子标志物、特殊信号通路、基因表达及免疫应答等,为脑恶性肿瘤的评估、诊断、分型和治疗提供了新的思路。本文将对单细胞测序及其与未来脑恶性肿瘤的诊疗进展进行综述。
    利益冲突  无
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  • 收稿日期:  2018-06-19
  • 刊出日期:  2020-09-30

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