Abstract: Hepatocellular carcinoma(HCC) is one of the most common malignant tumors in China. Transcatheter arterial chemoembolization(TACE) is currently the most widely used locoregional treatment for unresectable HCC. With the development of technology, TACE has improved in the safety and efficacy and expanded the scope of treatment indications. The aim of this article is to summarize the latest technology and future development of TACE including TACE with drug-eluting beads in the treatment of advanced primary HCC, in order to provide guidance for clinical decision-making.