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PTEN基因与消化系统器官纤维化

张晓云 郝建宇

张晓云, 郝建宇. PTEN基因与消化系统器官纤维化[J]. 协和医学杂志, 2017, 8(4-5): 300-304. doi: 10.3969/j.issn.1674-9081.2017.05.020
引用本文: 张晓云, 郝建宇. PTEN基因与消化系统器官纤维化[J]. 协和医学杂志, 2017, 8(4-5): 300-304. doi: 10.3969/j.issn.1674-9081.2017.05.020
Xiao-yun ZHANG, Jian-yu HAO. PTEN and Digestive Organ Fibrosis[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 300-304. doi: 10.3969/j.issn.1674-9081.2017.05.020
Citation: Xiao-yun ZHANG, Jian-yu HAO. PTEN and Digestive Organ Fibrosis[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 300-304. doi: 10.3969/j.issn.1674-9081.2017.05.020

PTEN基因与消化系统器官纤维化

doi: 10.3969/j.issn.1674-9081.2017.05.020
基金项目: 

国家自然科学基金面上项目 81470888

详细信息
    通讯作者:

    郝建宇  电话:010-85231714,E-mail: haojianyu@medmail.com.cn

  • 中图分类号: R57;Q71

PTEN and Digestive Organ Fibrosis

More Information
  • 摘要: PTEN基因是目前发现的重要抑癌基因之一, 其蛋白产物具有独特的蛋白磷酸酶及脂质磷酸酶双重活性。PTEN蛋白分布广泛、生物学功能复杂、调节方式多样, 可通过多种信号转导途径对细胞的形态、增殖、分化、黏附、迁移等发挥调节作用。随着对PTEN基因的深入研究, 揭示该基因与多种消化器官纤维化过程密切相关, 并可能成为逆转及治疗纤维化的潜在靶点。
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出版历程
  • 收稿日期:  2017-02-09
  • 刊出日期:  2017-09-30

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