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PTEN基因与消化系统器官纤维化

张晓云,  郝建宇

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文章导航 > 协和医学杂志  > 2017 >  8(4-5): 300-304
张晓云, 郝建宇. PTEN基因与消化系统器官纤维化[J]. 协和医学杂志, 2017, 8(4-5): 300-304. doi: 10.3969/j.issn.1674-9081.2017.05.020
引用本文: 张晓云, 郝建宇. PTEN基因与消化系统器官纤维化[J]. 协和医学杂志, 2017, 8(4-5): 300-304. doi: 10.3969/j.issn.1674-9081.2017.05.020
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Xiao-yun ZHANG, Jian-yu HAO. PTEN and Digestive Organ Fibrosis[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 300-304. doi: 10.3969/j.issn.1674-9081.2017.05.020
Citation: Xiao-yun ZHANG, Jian-yu HAO. PTEN and Digestive Organ Fibrosis[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 300-304. doi: 10.3969/j.issn.1674-9081.2017.05.020
shu

PTEN基因与消化系统器官纤维化

doi: 10.3969/j.issn.1674-9081.2017.05.020

  • 首都医科大学附属北京朝阳医院消化内科, 北京 100020

基金项目: 

国家自然科学基金面上项目 81470888

详细信息
    通讯作者:

    郝建宇  电话:010-85231714,E-mail: haojianyu@medmail.com.cn

  • 中图分类号: R57;Q71

PTEN and Digestive Organ Fibrosis

  • Department of Gastroenterology, Beijing Chaoyang Hospital Affiliated to Capital Medical University, Beijing 100020

More Information

    摘要
  • 摘要: PTEN基因是目前发现的重要抑癌基因之一, 其蛋白产物具有独特的蛋白磷酸酶及脂质磷酸酶双重活性。PTEN蛋白分布广泛、生物学功能复杂、调节方式多样, 可通过多种信号转导途径对细胞的形态、增殖、分化、黏附、迁移等发挥调节作用。随着对PTEN基因的深入研究, 揭示该基因与多种消化器官纤维化过程密切相关, 并可能成为逆转及治疗纤维化的潜在靶点。
    Abstract: PTEN gene is one of the most important tumor suppressor gene, which acts through a unique protein phosphatase and lipid phosphates activity. PTEN protein has a wide distribution, complex biological function, and a variety of regulation modes, which can regulate the cell morphology, proliferation, differentiation, adhesion and migration through a variety of signaling pathways. With the further study of PTEN, it is found that the gene is closely related to the digestive process of many kinds of digestive organs, and may be a potential target for the reversing and treatment of fibrosis.
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    • 参考文献(42)
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出版历程
  • 收稿日期:  2017-02-09
  • 刊出日期:  2017-09-30

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