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微小RNA在结节性硬化症相关病变中的研究进展

郭浩,  王文达,  蔡燚,  张玉石

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文章导航 > 协和医学杂志  > 2017 >  8(4-5): 283-288
郭浩, 王文达, 蔡燚, 张玉石. 微小RNA在结节性硬化症相关病变中的研究进展[J]. 协和医学杂志, 2017, 8(4-5): 283-288. doi: 10.3969/j.issn.1674-9081.2017.05.017
引用本文: 郭浩, 王文达, 蔡燚, 张玉石. 微小RNA在结节性硬化症相关病变中的研究进展[J]. 协和医学杂志, 2017, 8(4-5): 283-288. doi: 10.3969/j.issn.1674-9081.2017.05.017
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Hao GUO, Wen-da WANG, Yi CAI, Yu-shi ZHANG. Progress in Research on MicroRNA in Tuberous Sclerosis Complex Related Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 283-288. doi: 10.3969/j.issn.1674-9081.2017.05.017
Citation: Hao GUO, Wen-da WANG, Yi CAI, Yu-shi ZHANG. Progress in Research on MicroRNA in Tuberous Sclerosis Complex Related Diseases[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 283-288. doi: 10.3969/j.issn.1674-9081.2017.05.017
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微小RNA在结节性硬化症相关病变中的研究进展

doi: 10.3969/j.issn.1674-9081.2017.05.017

  • 中国医学科学院 北京协和医学院 北京协和医院泌尿外科, 北京 100730

基金项目: 

国家自然科学基金 81670611

北京协和医院中青年科研基金 pumch-2016-2.11

详细信息
    通讯作者:

    张玉石  电话:010-69152510,E-mail:zhangyushi333@126.com

  • 中图分类号: R596.1

Progress in Research on MicroRNA in Tuberous Sclerosis Complex Related Diseases

  • Department of Urology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要: 结节性硬化症(tuberous sclerosis complex, TSC)是一种累及多个器官和系统的常染色体显性遗传疾病, 几乎可累及人体所有器官及系统。TSC常表现为皮肤病性损害及内脏良性肿瘤, 亦有少部分恶性程度较高的肿瘤, 例如室管膜下巨细胞星形细胞瘤(subependymal giant cell astrocytoma, SEGA)、肾细胞癌等。越来越多的证据表明, 微小RNA与TSC相关病变的发生有密切关系, 起着癌基因或抑癌基因的作用。本文针对微小RNA在TSC相关病变如肺及神经系统疾病中的研究进展作一综述。
    Abstract: Tuberous sclerosis complex(TSC) is an autosomal dominant genetic disease involving multiple organs and systems. It can involve all organs and systems in the body. Nodular sclerosis is often manifested as skin lesions and visceral benign tumors, as well as a small number of highly malignant tumors, such as subependymal giant cell astrocytoma(SEGA), renal cell carcinoma and so on. There is growing evidence that microRNAs(miRNAs) are closely related to TSC related diseases and act as oncogenes or tumor suppressor genes. This paper reviews the progress of study on miRNA in several diseases related to tuberous sclerosis complex.
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    • 参考文献(40)
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出版历程
  • 收稿日期:  2017-06-26
  • 刊出日期:  2017-09-30

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