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CD8+ T淋巴细胞在原发性胆汁性胆管炎发病机制中的调控与作用

陶葸茜,  王立,  张奉春

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文章导航 > 协和医学杂志  > 2017 >  8(4-5): 278-282
陶葸茜, 王立, 张奉春. CD8+ T淋巴细胞在原发性胆汁性胆管炎发病机制中的调控与作用[J]. 协和医学杂志, 2017, 8(4-5): 278-282. doi: 10.3969/j.issn.1674-9081.2017.05.016
引用本文: 陶葸茜, 王立, 张奉春. CD8+ T淋巴细胞在原发性胆汁性胆管炎发病机制中的调控与作用[J]. 协和医学杂志, 2017, 8(4-5): 278-282. doi: 10.3969/j.issn.1674-9081.2017.05.016
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Xi-xi TAO, Li WANG, Feng-chun ZHANG. CD8+ T Cells in the Pathogenesis of Primary Biliary Cholangitis[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 278-282. doi: 10.3969/j.issn.1674-9081.2017.05.016
Citation: Xi-xi TAO, Li WANG, Feng-chun ZHANG. CD8+ T Cells in the Pathogenesis of Primary Biliary Cholangitis[J]. Medical Journal of Peking Union Medical College Hospital, 2017, 8(4-5): 278-282. doi: 10.3969/j.issn.1674-9081.2017.05.016
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CD8+ T淋巴细胞在原发性胆汁性胆管炎发病机制中的调控与作用

doi: 10.3969/j.issn.1674-9081.2017.05.016
  • 1.

    中国医学科学院 北京协和医学院 北京协和医院 风湿免疫科, 北京 100730

  • 2.

    中国医学科学院 北京协和医学院 北京协和医院 超声医学科, 北京 100730

基金项目: 

国家自然科学基金面上项目 81571594

国家自然科学基金青年项目 81501414

国家自然科学基金青年项目 81501410

国家自然科学基金青年项目 81501413

首都卫生发展科研专项青年项目 2016-4-40111

详细信息
    通讯作者:

    王立  电话:010-69158770,E-mail:wangli2221@sina.com

  • 中图分类号: R575.7;R392.3

CD8+ T Cells in the Pathogenesis of Primary Biliary Cholangitis

  • 1.

    Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Department of Ultrasound, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information

    摘要
  • 摘要: 原发性胆汁性胆管炎(primary biliary cholangitis, PBC)是一种以肝脏损害为主要表现的自身免疫性疾病, 其发病机制目前尚不明确, 可能与多种因素相关。其中, 在PBC的免疫功能紊乱中, CD8+ T淋巴细胞介导的细胞免疫有重要作用, 与PBC患者肝脏胆管上皮细胞受损有关。本文主要讨论CD8+ T细胞在PBC发病机制中的调控及该群细胞对PBC肝脏的损害作用。
    Abstract: Primary biliary cholangitis(PBC) is an autoimmune disease characterized by the liver damage. The pathogenesis of PBC is not fully understood currently, and many factors are involved. The cellular immunity mediated by CD8+ T cells plays an important role in the immune dysregulation of PBC, which is related to the injury of biliary epithelial cells. This review is mainly about the regulation of CD8+ T cells that involves several mechanisms, and the function of this group of cells in the liver damage of PBC patients.
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    • 参考文献(26)
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出版历程
  • 收稿日期:  2017-06-26
  • 刊出日期:  2017-09-30

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