留言板

尊敬的读者、作者、审稿人, 关于本刊的投稿、审稿、编辑和出版的任何问题, 您可以本页添加留言。我们将尽快给您答复。谢谢您的支持!

姓名
邮箱
手机号码
标题
留言内容
验证码

内质网应激与微小核糖核酸在胰岛β细胞凋亡中的作用

吉慧珍 孙琦 杨静 邢小平

吉慧珍, 孙琦, 杨静, 邢小平. 内质网应激与微小核糖核酸在胰岛β细胞凋亡中的作用[J]. 协和医学杂志, 2016, 7(1): 48-52. doi: 10.3969/j.issn.1674-9081.2016.01.010
引用本文: 吉慧珍, 孙琦, 杨静, 邢小平. 内质网应激与微小核糖核酸在胰岛β细胞凋亡中的作用[J]. 协和医学杂志, 2016, 7(1): 48-52. doi: 10.3969/j.issn.1674-9081.2016.01.010

内质网应激与微小核糖核酸在胰岛β细胞凋亡中的作用

doi: 10.3969/j.issn.1674-9081.2016.01.010
详细信息
    通讯作者:

    孙琦 电话:010-69155084, E-mail:sunqi@pumch.cn

  • 中图分类号: R587.1;Q756

  • [1] Butler AE, Janson J, Bonner-Weir S, et al. Beta-cell deficit and increased beta-cell apoptosis in human with type 2 diabetes[J]. Diabetes, 2003, 52: 102-110. doi:  10.2337/diabetes.52.1.102
    [2] Schroder M, Kaufman RJ.The mammalian unfolded protein response[J].Annu Rev Biochem, 2005, 74: 739-789. doi:  10.1146/annurev.biochem.73.011303.074134
    [3] Bernales S, Papa FR, Walter P, et al. Intracellular signaling by the unfolded protein response[J].Annu Rev Cell Dev Biol, 2006, 22:487-508. doi:  10.1146/annurev.cellbio.21.122303.120200
    [4] Ron D, Walter P. Signal integration in the endoplasmic reticulum unfolded protein response[J]. Nat Rev Mol Cell Biol, 2007, 8: 519-529. doi:  10.1038/nrm2199
    [5] Han D, Lerner AG, Vande Walle L, et al. IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates[J]. Cell, 2009, 138: 562-575. doi:  10.1016/j.cell.2009.07.017
    [6] Upton JP, Wang L, Han D, et al.IRE1α cleaves select microRNAs during ER stress to derepress translation of proapoptotic Caspase-2[J]. Science, 2012, 338: 818-822. doi:  10.1126/science.1226191
    [7] Lerner AG, Upton JP, Praveen PV, et al. IRE1α induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress[J].Cell Metab, 2012, 16: 250-264. doi:  10.1016/j.cmet.2012.07.007
    [8] Hetz C, Bernasconi P, Fisher J, et al. Proapoptotic BAX and BAK modulate the unfolded protein response by a direct interaction with IRE1alpha[J]. Science, 2006, 312: 572-576. doi:  10.1126/science.1123480
    [9] Urano F, Wang X, Bertolotti A, et al. Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1[J]. Science, 2000, 287: 664-666. doi:  10.1126/science.287.5453.664
    [10] Hu P, Han Z, Couvillon AD, et al.Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression[J]. Mol Cell Biol, 2006, 26: 3071-3084. doi:  10.1128/MCB.26.8.3071-3084.2006
    [11] Lange PS, Chavez JC, Pinto JT, et al.ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo[J]. J Exp Med, 2008, 205: 1227-1242. doi:  10.1084/jem.20071460
    [12] Hiramatsu N, Messah C, Han J, et al. Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response[J].Mol Biol Cell, 2014, 25: 1411-1420. doi:  10.1091/mbc.e13-11-0664
    [13] Oslowski CM, Hara T, O'Sullivan-Murphy B, et al. Thioredoxin-interacting protein mediates ER stress-induced β cell death through initiation of the inflammasome[J]. Cell Metab, 2012, 16: 265-273. doi:  10.1016/j.cmet.2012.07.005
    [14] Laybutt DR, Preston AM, Akerfeldt MC, et al. Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes[J]. Diabetologia, 2007, 50:752-763. doi:  10.1007/s00125-006-0590-z
    [15] Lipson KL, Fonseca SG, Ishigaki S, et al. Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1[J]. Cell Metab, 2006, 4:245-254. doi:  10.1016/j.cmet.2006.07.007
    [16] Wali JA, Rondas D, Thomas HE, et al. The proapoptotic BH3-only proteins Bim and Puma are downstream of endoplasmic reticulum and mitochondrial oxidative stress in pancreatic islets in response to glucotoxicity[J]. Cell Death Dis, 2014, 5: e1124. doi:  10.1038/cddis.2014.88
    [17] Zheng X, Zheng X, Pereira TS, et al.Acute hypoxia induces apoptosis of pancreatic β-cell by activation of the unfolded protein response and upregulation of CHOP[J]. Cell Death Dis, 2012, 3: e322. doi:  10.1038/cddis.2012.66
    [18] Hirata T, Kawai T, Itoh H, et al.Palmitic acid-rich diet suppresses glucose-stimulated insulin secretion (GSIS) and induces endoplasmic reticulum (ER) stress in pancreatic islets in mice[J]. Endocr Res, 2015, 13:1-8. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=10.3109/07435800.2015.1038352
    [19] Wali JA, Gurzov EN, Thomas HE, et al.Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets[J].PLoS One, 2014, 9:e113128. doi:  10.1371/journal.pone.0113128
    [20] Němcová-Fürstová V, Balušíková K, Srámek J, et al. Caspase-2 and JNK activated by saturated fatty acids are not involved in apoptosis induction but modulate ER stress in human pancreatic β-cells[J]. Cell Physiol Biochem, 2013, 31:277-289. doi:  10.1159/000343367
    [21] Song B, Scheuner D, Ron D, et al. Chop deletion reduces oxidative stress, improves β cell function, and promotes cell survival in multiple mouse models of diabetes[J]. J Clin Invest, 2008, 118: 3378-3389. doi:  10.1172/JCI34587
    [22] 孙琦, 向若兰, 张文龙, 等. 4-苯基丁酸抗内质网应激诱导胰岛B细胞凋亡[J].解剖学报, 2012, 43: 784-788. http://d.wanfangdata.com.cn/Periodical/jpxb201206013
    [23] Marchetti P, Bugliani M, Lupi R, et al. The endoplasmic reticulum in pancreatic beta cells of type diabetes patients[J]. Diabetologia, 2007, 50:2486-2494. doi:  10.1007/s00125-007-0816-8
    [24] Omikorede O, Qi C, Herbert TP, et al. ER stress in rodent islets of Langerhans is concomitant with obesity and beta-cell compensation but not with beta-cell dysfunction and diabetes[J]. Nutr Diabetes, 2013, 3: e93. doi:  10.1038/nutd.2013.35
    [25] Chan JY, Luzuriaga J, Laybutt DR, et al. Failure of the adaptive unfolded protein response in islets of obese mice is linked with abnormalities in beta-cell gene expression and progression to diabetes[J]. Diabetes, 2013, 62: 1557-1568. doi:  10.2337/db12-0701
    [26] Engin F, Nguyen T, Yermalovich A, et al. Aberrant islet unfolded protein response in type 2 diabetes[J]. Sci Rep, 2014, 4:4054. http://www.ncbi.nlm.nih.gov/pubmed/24514745
    [27] Chan JY, Luzuriaga J, Maxwell EL, et al.The balance between adaptive and apoptotic unfolded protein responses regulates b-cell death under ER stress conditions through XBP1, CHOP and JNK[J]. Mol Cell Endocrinol, 2015, 413: 189-201. doi:  10.1016/j.mce.2015.06.025
    [28] Friedman RC, Farh KK, Burge CB, et al.Most mammalian mRNAs are conserved targets of microRNAs[J].Genome Res, 2009, 19:92-105. http://www.bioone.org/servlet/linkout?suffix=bibr16&dbid=8&doi=10.1603%2FAN12158&key=18955434
    [29] Roggli E, Gattesco S, Caille D, et al.Changes in micro-RNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice[J]. Diabetes, 2012, 61: 1742-1751. doi:  10.2337/db11-1086
    [30] Roggli E, Britan A, Gattesco S, et al. Involvement of microRNAs in the cytotoxic effects exerted by proinflammatory cytokines on pancreatic beta-cells[J].Diabetes, 2010, 59:978-986. doi:  10.2337/db09-0881
    [31] Lin X, Guan H, Huang Z, et al.Downregulation of Bcl-2 expression by miR-34a mediates palmitate-induced Min6 cells apoptosis[J].J Diabetes Res, 2014, 2014:258695. http://www.ncbi.nlm.nih.gov/pubmed/24829923
    [32] Ruan Q, Wang T, Kameswaran V, et al. The microRNA-21-PDCD4 axis prevents type 1 diabetes by blocking pancreatic beta cell death[J].Proc Natl Acad Sci, 2011, 108:12030-12035. doi:  10.1073/pnas.1101450108
    [33] Jacovetti C, Abderrahmani A, Parnaud G, et al. MicroRNAs contribute to compensatory beta cell expansion during pregnancy and obesity[J].J Clin Invest, 2012, 122:3541-3551. doi:  10.1172/JCI64151
    [34] Nesca V, Guay C, Jacovetti C, et al.Identification of particular groups of microRNAs that positively or negatively impact on beta cell function in obese models of type 2 diabetes[J].Diabetologia, 2013, 56:2203-2212. doi:  10.1007/s00125-013-2993-y
    [35] Li Y, Xu X, Liang Y, et al.miR-375 enhances palmitate-induced lipoapoptosis in insulin-secreting NIT-1 cells by repressing myotrophin (V1) protein expression[J].Int J Clin Exp Pathol, 2010, 3:254-264. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=PubMed000002283367
    [36] Guay C, Menoud V, Rome S, et al.Horizontal transfer of exosomal microRNAs transduce apoptotic signals between pancreatic beta-cells[J].Cell Commun Signal, 2015, 19: 13-17.
    [37] Hofmann S, Cherkasova V, Bankhead P, et al.Translation suppression promotes stress granule formation and cell survival in response to cold shock[J].Mol Biol Cell, 2012, 23:3786-3800. doi:  10.1091/mbc.e12-04-0296
    [38] Leung AK, Calabrese JM, Sharp PA.Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules[J].Proc Natl Acad Sci USA, 2006, 103:18125-18130. doi:  10.1073/pnas.0608845103
    [39] Bartoszewska S, Kochan K, Madanecki P, et al.Regulation of the unfolded protein response by microRNAs[J].Cell Mol Biol Lett, 2013, 18:555-578. doi:  10.2478/s11658-013-0106-z
    [40] Cawley K, Logue SE, Gorman AM, et al.Disruption of microRNA biogenesis confers resistance to ER stress-induced cell death upstream of the mitochondrion[J].PLoS One, 2013, 8:e73870. doi:  10.1371/journal.pone.0073870
    [41] Filios SR, Xu G, Chen J, et al.MicroRNA-200 is induced by thioredoxin-interacting protein and regulates Zeb1 protein signaling and beta cell apoptosis[J].J Biol Chem, 2014, 289:36275-36283. doi:  10.1074/jbc.M114.592360
  • 加载中
计量
  • 文章访问数:  130
  • HTML全文浏览量:  54
  • PDF下载量:  3
  • 被引次数: 0
出版历程
  • 收稿日期:  2015-08-04
  • 刊出日期:  2016-01-30

目录

    /

    返回文章
    返回

    【温馨提醒】近日,《协和医学杂志》编辑部接到作者反映,有多名不法人员冒充期刊编辑发送见刊通知,鼓动作者添加微信,从而骗取版面费的行为。特提醒您,本刊与作者联系的方式均为邮件通知或电话,稿件进度通知邮箱为:mjpumch@126.com,编辑部电话为:010-69154261,请提高警惕,谨防上当受骗!如有任何疑问,请致电编辑部核实。谢谢!