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新型人工生物补片作为主动脉瓣替代材料的可行性

刘剑州 刘兴荣 张超纪 马国涛 李晓凤 苗齐

刘剑州, 刘兴荣, 张超纪, 马国涛, 李晓凤, 苗齐. 新型人工生物补片作为主动脉瓣替代材料的可行性[J]. 协和医学杂志, 2015, 6(4): 271-274. doi: 10.3969/j.issn.1674-9081.2015.04.007
引用本文: 刘剑州, 刘兴荣, 张超纪, 马国涛, 李晓凤, 苗齐. 新型人工生物补片作为主动脉瓣替代材料的可行性[J]. 协和医学杂志, 2015, 6(4): 271-274. doi: 10.3969/j.issn.1674-9081.2015.04.007
Jian-zhou LIU, Xing-rong LIU, Chao-ji ZHANG, Guo-tao MA, Xiao-feng LI, Qi MIAO. Feasibility of New Artificial Biologic Patch as Aortic Valve Replacement[J]. Medical Journal of Peking Union Medical College Hospital, 2015, 6(4): 271-274. doi: 10.3969/j.issn.1674-9081.2015.04.007
Citation: Jian-zhou LIU, Xing-rong LIU, Chao-ji ZHANG, Guo-tao MA, Xiao-feng LI, Qi MIAO. Feasibility of New Artificial Biologic Patch as Aortic Valve Replacement[J]. Medical Journal of Peking Union Medical College Hospital, 2015, 6(4): 271-274. doi: 10.3969/j.issn.1674-9081.2015.04.007

新型人工生物补片作为主动脉瓣替代材料的可行性

doi: 10.3969/j.issn.1674-9081.2015.04.007
基金项目: 

北京协和医院中青年基金 pumch-2013-003

详细信息
    通讯作者:

    苗齐 电话:010-69152829, E-mail:miaoqipumc@hotmail.com

  • 中图分类号: R605

Feasibility of New Artificial Biologic Patch as Aortic Valve Replacement

More Information
  • 摘要:   目的  探讨胶原膜与碱性成纤维细胞生长因子(base fibroblast growth factor, bFGF)特异结合的人工生物补片作为主动脉瓣膜替代材料的可行性。  方法  健康杂种家犬10只随机分为对照组和实验组, 每组5只, 静脉全麻、腹主动脉阻断下分别使用仅浸泡磷酸盐缓冲液的胶原膜材料或特异结合bFGF的胶原膜材料作为人工瓣膜行腹主动脉腔内移植。于术后3个月利用超声心动图对人工瓣膜的功能进行评价, 于术后6个月取材观察人工瓣膜状况。  结果  术后3个月超声心动图检测人工瓣膜的功能在对照组和实验组之间无差别, 术后6个月对照组及实验组犬腹主动脉腔内的人工瓣膜均降解。  结论  胶原膜与bFGF特异结合的人工生物补片在体内的降解速率较快, 目前尚不能作为主动脉瓣膜良好的替代材料。
  • 图  1  犬腹主动脉手术模型的建立及人工瓣膜移植于腹主动脉

    A.术中游离腹主动脉;B.剪开腹主动脉,并将功能材料缝合到其壁上;C.腹主动脉缝合完毕

    图  2  超声心动图检测犬腹主动脉腔内植入的人工瓣膜形态

    A.血管纵切面,虚线以下示部分人工瓣膜;B.血管横切面,箭头示部分人工瓣膜

    图  3  植入6个月后的犬腹主动脉中未见人工瓣膜,提示其在腔内已降解

    A.腹主动脉外观图; B.腹主动脉切开后剖面图

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    [2] Jamieson WR, von Lipinski O, Miyagishima RT, et al. Performance of bioprostheses and mechanical prostheses assessed by composites of valve-related complications to 15 years after mitral valve replacement[J]. J Thorac Cardiovasc Surg, 2005, 129:1301-1308. doi:  10.1016/j.jtcvs.2004.09.042
    [3] Jamieson WR, Gudas VM, Burr LH, et al. Mitral valve disease:if the mitral valve is not reparable/failed repair, is bioprosthesis suitable for replacement?[J]. Eur J Cardiothorac Surg, 2009, 35:104-110. doi:  10.1016/j.ejcts.2008.08.021
    [4] Zhang J, Ding L, Zhao Y, et al. Collagen-targeting vascular endothelial growth factor improves cardiac performance after myocardial infarction[J]. Circulation, 2009, 119:1776-1784. doi:  10.1161/CIRCULATIONAHA.108.800565
    [5] Gao J, Liu J, Gao Y, et al. A myocardial patch made of collagen membranes loaded with collagen-binding human vascular endothelial growth factor accelerates healing of the injured rabbit heart[J]. Tissue Eng Part A, 2011, 17:2739-2747. doi:  10.1089/ten.tea.2011.0105
    [6] Feng C, Zhang C, Shao X, et al. Enhancement of nose-to-brain delivery of basic fibroblast growth factor for improving rat memory impairments induced by co-injection of β-amyloid and ibotenic acid into the bilateral hippocampus[J]. Int J Pharm, 2012, 423:226-234. doi:  10.1016/j.ijpharm.2011.12.008
    [7] Yasuda Y, Koyama H, Tabata Y, et al. Controlled delivery of bFGF remodeled vascular network in muscle flap and increased perfusion capacity via minor pedicle[J]. J Surg Res, 2008, 147:132-137. doi:  10.1016/j.jss.2007.10.009
    [8] Park CJ, Clark SG, Lichtensteiger CA, et al. Accelerated wound closure of pressure ulcers in aged mice by chitosan scaffolds with and without bFGF[J]. Acta Biomater, 2009, 5:1926-1936. doi:  10.1016/j.actbio.2009.03.002
    [9] Burdzińska A, Bartoszuk U, Orzechowski A. Preincubation with bFGF but not sodium ascorbate improves efficiency of autologous transplantation of muscle-derived cells into urethral wall[J]. Urology, 2009, 73:736-742. doi:  10.1016/j.urology.2008.11.024
    [10] Lee H, Cusick RA, Browne F, et al. Local delivery of basic fibroblast growth factor increases both angiogenesis and engraftment of hepatocytes in tissue-engineered polymer devices[J]. Transplantation, 2002, 73:1589-1593. doi:  10.1097/00007890-200205270-00011
    [11] Perets A, Baruch Y, Weisbuch F, et al. Enhancing the vascularization of three-dimensional porous alginate scaffolds by incorporating controlled release basic fibroblast growth factor microspheres[J]. J Biomed Mater Res A, 2003, 65:489-497. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=6ddc6c5e3885531d3d650dbf7aa999da
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出版历程
  • 收稿日期:  2014-10-13
  • 刊出日期:  2015-07-30

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