粪菌移植治疗孤独症谱系障碍的研究进展

李晓燕; 徐新杰; 罗欣; 尤欣

doi:10.12290/xhyxzz.2022-0301

粪菌移植治疗孤独症谱系障碍的研究进展

doi: 10.12290/xhyxzz.2022-0301

李晓燕¹,
徐新杰²,
罗欣¹,
尤欣^1, ,

1.
中国医学科学院北京协和医院风湿免疫科，北京 100730
2.
中国医学科学院北京协和医院医学科学研究中心，北京 100730

基金项目:

中国医学科学院医学与健康科技创新工程 2017-I2M-3-017

中国医学科学院中央级公益性科研院所基本科研业务费专项资金 2019XK320030

详细信息

通讯作者:
尤欣, E-mail: youxin@pumch.cn

中图分类号: R392;R749.93
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出版历程
- 收稿日期: 2022-05-30
- 录用日期: 2022-07-28
- 网络出版日期: 2022-08-12
- 刊出日期: 2022-09-30

Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation

LI Xiaoyan¹,
XU Xinjie²,
LUO Xin¹,
YOU Xin^{1
, ,}

1.
Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2.
Medical Research Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

CAMS Innovation Fund for Medical Sciences 2017-I2M-3-017

Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2019XK320030

More Information

Corresponding author: YOU Xin, E-mail: youxin@pumch.cn

摘要

摘要: 孤独症谱系障碍(autism spectrum disorder，ASD) 是发病于儿童早期的神经发育障碍性疾病，目前尚无有效的治愈手段。其发病率近年来明显上升，给患者家庭和社会带来了沉重负担。ASD患者多存在胃肠道症状和肠道菌群失衡，研究发现ASD患者的胃肠道功能障碍与肠道菌群结构变化密切相关，且通过粪菌移植可显著改善ASD相关症状。本文通过总结粪菌移植治疗ASD的最新研究进展，以期为ASD的治疗提供新思路。
- 孤独症 /
- 粪菌移植 /
- 发育障碍 /
- 肠道菌群
Abstract: Autism spectrum disorder (ASD), a neurodevelopmental disorder during early childhood, currently has no effective treatment. The prevalence of ASD has been increasing, which brings a heavy burden to the family of the patients and the society. Children with ASD are accompanied by gastrointestinal symptoms and have an imbalance of intestinal microbiota. Fecal microbiota transplantation (FMT) can improve autism-related symptoms in children with ASD. This review aims to summarize the research progress of FMT for treating ASD to provide a novel strategy for this untreatable disease.
- autism /
- fecal microbiota transplantation /
- developmental disorders /
- intestinal flora
注释:

作者贡献：李晓燕负责资料收集、初稿撰写; 罗欣负责论文修订; 尤欣、徐新杰负责论文修订、终审校对。

利益冲突：所有作者均声明不存在利益冲突

HTML全文

表 1 FMT治疗ASD患者各途径比较

途径	适宜人群	优点	缺点
口服胶囊	会吞咽胶囊的轻中度ASD患者	操作简单、方便，可多次FMT	胶囊的制作和检测尚无统一标准
鼻空肠管	无感觉异常，无兴奋或多动的ASD患者	可长期留置，多次FMT	操作难度大，易导致鼻咽部不适
TET	有一定认知理解力，可带管生活的轻度ASD患者	可肠道内一定时间留置，肠道深部多次FMT，减少患者痛苦	存在拔管风险，可导致腹部及肛门不适感
无痛电子结肠镜	无麻醉禁忌的ASD患者	完整展示结肠结构，一次性输送较大菌量，治疗效果显著，患者痛苦小	需麻醉，存在手术风险，不便于重复操作
灌肠	无感觉异常且能配合的轻度ASD患者	方便易行	无法将菌液输送至回盲部，存在肛门不适感，易产生恐惧心理
ASD：孤独症谱系障碍；FMT：粪菌移植；TET：经内镜肠道植管术

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粪菌移植治疗孤独症谱系障碍的研究进展

doi: 10.12290/xhyxzz.2022-0301

通讯作者:
尤欣, E-mail: youxin@pumch.cn

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Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation

Corresponding author: YOU Xin, E-mail: youxin@pumch.cn

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留言板

粪菌移植治疗孤独症谱系障碍的研究进展

doi: 10.12290/xhyxzz.2022-0301

通讯作者: 尤欣, E-mail: youxin@pumch.cn

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出版历程

Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation

Corresponding author: YOU Xin, E-mail: youxin@pumch.cn

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出版历程

目录

通讯作者:
尤欣, E-mail: youxin@pumch.cn