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粪菌移植治疗孤独症谱系障碍的研究进展

李晓燕 徐新杰 罗欣 尤欣

李晓燕, 徐新杰, 罗欣, 尤欣. 粪菌移植治疗孤独症谱系障碍的研究进展[J]. 协和医学杂志, 2022, 13(5): 753-759. doi: 10.12290/xhyxzz.2022-0301
引用本文: 李晓燕, 徐新杰, 罗欣, 尤欣. 粪菌移植治疗孤独症谱系障碍的研究进展[J]. 协和医学杂志, 2022, 13(5): 753-759. doi: 10.12290/xhyxzz.2022-0301
LI Xiaoyan, XU Xinjie, LUO Xin, YOU Xin. Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 753-759. doi: 10.12290/xhyxzz.2022-0301
Citation: LI Xiaoyan, XU Xinjie, LUO Xin, YOU Xin. Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 753-759. doi: 10.12290/xhyxzz.2022-0301

粪菌移植治疗孤独症谱系障碍的研究进展

doi: 10.12290/xhyxzz.2022-0301
基金项目: 

中国医学科学院医学与健康科技创新工程 2017-I2M-3-017

中国医学科学院中央级公益性科研院所基本科研业务费专项资金 2019XK320030

详细信息
    通讯作者:

    尤欣, E-mail: youxin@pumch.cn

  • 中图分类号: R392;R749.93

Research Progress in the Treatment of Autism Spectrum Disorder with Fecal Microbiota Transplantation

Funds: 

CAMS Innovation Fund for Medical Sciences 2017-I2M-3-017

Non-Profit Central Research Institute Fund of Chinese Academy of Medical Sciences 2019XK320030

More Information
  • 摘要: 孤独症谱系障碍(autism spectrum disorder,ASD) 是发病于儿童早期的神经发育障碍性疾病,目前尚无有效的治愈手段。其发病率近年来明显上升,给患者家庭和社会带来了沉重负担。ASD患者多存在胃肠道症状和肠道菌群失衡,研究发现ASD患者的胃肠道功能障碍与肠道菌群结构变化密切相关,且通过粪菌移植可显著改善ASD相关症状。本文通过总结粪菌移植治疗ASD的最新研究进展,以期为ASD的治疗提供新思路。
    作者贡献:李晓燕负责资料收集、初稿撰写; 罗欣负责论文修订; 尤欣、徐新杰负责论文修订、终审校对。
    利益冲突:所有作者均声明不存在利益冲突
  • 表  1  FMT治疗ASD患者各途径比较

    途径 适宜人群 优点 缺点
    口服胶囊 会吞咽胶囊的轻中度ASD患者 操作简单、方便,可多次FMT 胶囊的制作和检测尚无统一标准
    鼻空肠管 无感觉异常,无兴奋或多动的ASD患者 可长期留置,多次FMT 操作难度大,易导致鼻咽部不适
    TET 有一定认知理解力,可带管生活的轻度ASD患者 可肠道内一定时间留置,肠道深部多次FMT,减少患者痛苦 存在拔管风险,可导致腹部及肛门不适感
    无痛电子结肠镜 无麻醉禁忌的ASD患者 完整展示结肠结构,一次性输送较大菌量,治疗效果显著,患者痛苦小 需麻醉,存在手术风险,不便于重复操作
    灌肠 无感觉异常且能配合的轻度ASD患者 方便易行 无法将菌液输送至回盲部,存在肛门不适感,易产生恐惧心理
    ASD:孤独症谱系障碍;FMT:粪菌移植;TET:经内镜肠道植管术
    下载: 导出CSV
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出版历程
  • 收稿日期:  2022-05-30
  • 录用日期:  2022-07-28
  • 网络出版日期:  2022-08-12
  • 刊出日期:  2022-09-30

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