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肠道菌群在自身免疫性疾病治疗中的前景

赵丽丹,  孟夏,  徐浩杰,  张奉春

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文章导航 > 协和医学杂志  > 2022 >  13(5): 740-746
赵丽丹, 孟夏, 徐浩杰, 张奉春. 肠道菌群在自身免疫性疾病治疗中的前景[J]. 协和医学杂志, 2022, 13(5): 740-746. doi: 10.12290/xhyxzz.2022-0245
引用本文: 赵丽丹, 孟夏, 徐浩杰, 张奉春. 肠道菌群在自身免疫性疾病治疗中的前景[J]. 协和医学杂志, 2022, 13(5): 740-746. doi: 10.12290/xhyxzz.2022-0245
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ZHAO Lidan, MENG Xia, XU Haojie, ZHANG Fengchun. Prospect of Gut Microbiota-based Intervention in Autoimmune Disease Control[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 740-746. doi: 10.12290/xhyxzz.2022-0245
Citation: ZHAO Lidan, MENG Xia, XU Haojie, ZHANG Fengchun. Prospect of Gut Microbiota-based Intervention in Autoimmune Disease Control[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 740-746. doi: 10.12290/xhyxzz.2022-0245
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肠道菌群在自身免疫性疾病治疗中的前景

doi: 10.12290/xhyxzz.2022-0245

  • 中国医学科学院北京协和医院风湿免疫科 国家皮肤与免疫疾病临床医学研究中心 风湿免疫病学教育部重点实验室，北京 100730

基金项目: 

国家自然科学基金 82071840

中国医学科学院医学与健康科技创新工程 2020-I2M-C & T-B-013

详细信息
    通讯作者:

    张奉春, E-mail: zhangfccra@aliyun.com

  • 中图分类号: R378; R593

Prospect of Gut Microbiota-based Intervention in Autoimmune Disease Control

  • Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Clinical Research Center for Dermatologic and Immunologic Diseases, Ministry of Education Key Laboratory, Beijing 100730, China

Funds: 

National Natural Science Foundation of China 82071840

CAMS Innovation Fund for Medical Sciences 2020-I2M-C & T-B-013

More Information

    摘要
  • 摘要: 肠道菌群对于维持人体免疫稳态不可或缺。肠道菌群失调、易位及菌群代谢物异常见于多种自身免疫性疾病，通过诱导免疫失衡、分子模拟、旁观者激活、表位扩展等机制参与自身免疫耐受破坏和过度炎症反应，促进自身免疫性疾病的发生发展，并通过干扰药物在肠道的转化影响免疫治疗药物的疗效和毒性。基于肠道菌群的干预措施或可为自身免疫性疾病的防治提供新策略。本文回顾近年来肠道菌群在系统性自身免疫性疾病中的研究进展，并对基于菌群的干预措施在自身免疫性疾病中的应用前景予以展望。
    Abstract: Gut microbiota is indispensable for the maintenance of human immune homeostasis. Dysbiosis and translocation of gut microbes as well as aberrance of microbiome metabolites, which are commonly seen in many autoimmune diseases, are suggested to participate in the breakdown of immune tolerance and the excessive inflammatory responses. The involved mechanisms include immune equilibrium skewing, molecular mimicry, bystander activation and epitope spreading, which contributes to the initiation and progression of autoimmune diseases. In addition, the microbial biotransformation of antirheumatic drugs help determine the bioactivity and toxicity of these drugs. Herein, gut microbiota-based intervention may shed light on developing novel strategies for prophylaxis and treatment of autoimmune diseases. In this review, recent advances in exploring the potential pathogenic role of gut microbiota in autoimmunity are summarized and the prospect of applying microbiota-based intervention in systemic autoimmune diseases is addressed.
    作者贡献：赵丽丹负责撰写论文初稿、修订论文；孟夏、徐浩杰负责文献检索和筛选；张奉春负责审校论文。
    利益冲突：所有作者均声明不存在利益冲突
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  • 收稿日期:  2022-05-02
  • 录用日期:  2022-07-15
  • 网络出版日期:  2022-07-28
  • 刊出日期:  2022-09-30

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