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局部麻醉透皮技术与整形美容手术

李默晗 孙丰润 王涛 贺渝淼 马超 黄宇光

李默晗, 孙丰润, 王涛, 贺渝淼, 马超, 黄宇光. 局部麻醉透皮技术与整形美容手术[J]. 协和医学杂志, 2022, 13(3): 358-362. doi: 10.12290/xhyxzz.2022-0044
引用本文: 李默晗, 孙丰润, 王涛, 贺渝淼, 马超, 黄宇光. 局部麻醉透皮技术与整形美容手术[J]. 协和医学杂志, 2022, 13(3): 358-362. doi: 10.12290/xhyxzz.2022-0044
LI Mohan, SUN Fengrun, WANG Tao, HE Yumiao, MA Chao, HUANG Yuguang. Transdermal Technology of Local Anesthetics in Plastic and Cosmetic Surgery[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 358-362. doi: 10.12290/xhyxzz.2022-0044
Citation: LI Mohan, SUN Fengrun, WANG Tao, HE Yumiao, MA Chao, HUANG Yuguang. Transdermal Technology of Local Anesthetics in Plastic and Cosmetic Surgery[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(3): 358-362. doi: 10.12290/xhyxzz.2022-0044

局部麻醉透皮技术与整形美容手术

doi: 10.12290/xhyxzz.2022-0044
基金项目: 

国家自然科学基金面上项目 81771205

详细信息
    通讯作者:

    马超, E-mail:machao@ibms.cams.cn

    李默晗、孙丰润对本文同等贡献

    李默晗、孙丰润对本文同等贡献

  • 中图分类号: R614.3;R622

Transdermal Technology of Local Anesthetics in Plastic and Cosmetic Surgery

Funds: 

National Natural Science Foundation of China 81771205

More Information
  • 摘要: 术中麻醉根据麻醉药物分布范围可分为全身麻醉和局部麻醉,其中局部麻醉在整形美容手术中的应用较为广泛。传统剂型经皮递送局麻药作用时间较短,且脂溶性差,限制了其在体表透皮方面的应用。近年来,随着麻醉技术的发展,新型体表镇痛局麻药递送系统可将涂抹于皮肤的药物递送至真皮层以阻滞神经末梢痛觉传入,从而达到镇痛的效果,提高了药物递送效率。此外,透皮给药相较于注射给药可显著增加给药安全性和患者舒适度。本文概述了常用的局麻药透皮吸收促进方法以及目前已上市的透皮局麻药物,并结合研究进展对局部麻醉透皮技术在整形美容手术中的应用和发展作一展望。
    作者贡献:李默晗、孙丰润负责查阅文献、文章撰写及修改;王涛、贺渝淼、黄宇光提供文章修改建议;马超负责文章立意、审核及修订。
    利益冲突:所有作者均声明不存在利益冲突
  • 图  1  透皮给药方式示意图

    表  1  常见的透皮给药局麻药剂型

    透皮给药方式 常见剂型
    传统经皮吸收途径 乳膏剂、微乳剂、凝胶剂、巴布剂、脂质体、传递体
    新型透皮给药系统
    (微针贴片)
    实心微针、涂层微针、聚合物微针、空心微针
    物理辅助促渗方法 超声、离子导入、激光辅助导入、电致孔
    下载: 导出CSV

    表  2  已上市的利多卡因透皮局麻药剂型与含量

    商品名 剂型 药物(含量)
    Lidoderm 巴布剂 利多卡因(5%)
    ZTlido 贴膏剂 利多卡因(1.8%)
    EMLA 乳膏剂 利多卡因(2.5%)+丙胺卡因(2.5%)
    Synera 贴片 利多卡因(7%)+丁卡因(7%)
    LenzaGel 凝胶 利多卡因(4%)+薄荷醇(1%)
    下载: 导出CSV
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出版历程
  • 收稿日期:  2022-02-02
  • 录用日期:  2022-04-06
  • 网络出版日期:  2022-04-25
  • 刊出日期:  2022-05-30

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