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青年男性亚急性小脑性共济失调的罕见病因

敖冬慧 刘昕超 彭斌 朱以诚 崔丽英 姚明

敖冬慧, 刘昕超, 彭斌, 朱以诚, 崔丽英, 姚明. 青年男性亚急性小脑性共济失调的罕见病因[J]. 协和医学杂志, 2021, 12(1): 110-113. doi: 10.12290/xhyxzz.20180433
引用本文: 敖冬慧, 刘昕超, 彭斌, 朱以诚, 崔丽英, 姚明. 青年男性亚急性小脑性共济失调的罕见病因[J]. 协和医学杂志, 2021, 12(1): 110-113. doi: 10.12290/xhyxzz.20180433
AO Dong-hui, LIU Xin-chao, PENG Bin, ZHU Yi-cheng, CUI Li-ying, YAO Ming. A Rare Cause of Subacute Cerebellar Ataxia in a Young Man[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(1): 110-113. doi: 10.12290/xhyxzz.20180433
Citation: AO Dong-hui, LIU Xin-chao, PENG Bin, ZHU Yi-cheng, CUI Li-ying, YAO Ming. A Rare Cause of Subacute Cerebellar Ataxia in a Young Man[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(1): 110-113. doi: 10.12290/xhyxzz.20180433

青年男性亚急性小脑性共济失调的罕见病因

doi: 10.12290/xhyxzz.20180433
详细信息
    通讯作者:

    姚明 电话:010-69156372,E-mail: pumchym2011@yahoo.com

  • 中图分类号: R747.9; R373.9

A Rare Cause of Subacute Cerebellar Ataxia in a Young Man

More Information
  • 摘要: 亚急性小脑性共济失调多见于非典型感染、自身免疫性疾病和副肿瘤性小脑变性。本文报道1例表现为亚急性小脑性共济失调患者,其病因罕见。该患者男性,31岁,亚急性起病,临床表现为小脑性共济失调,严重免疫抑制状态,经筛查发现人类免疫缺陷病毒(human immunodeficiency virus, HIV)抗体及核酸均阳性、脑脊液JC病毒DNA阳性,临床诊断为JC病毒小脑颗粒细胞神经元病,经抗逆转录病毒治疗后共济失调症状好转, 3个月后随访症状稳定。JC病毒小脑颗粒细胞神经元病是一种JC病毒感染引起的新型临床症候,目前报道较少,本例为国内首次报道。本病例提示HIV感染免疫抑制患者出现共济失调时需筛查JC病毒,免疫功能的恢复有助于控制JC病毒小脑颗粒细胞神经元病症状进展。
    作者贡献:敖冬慧负责收集、分析临床资料,撰写本文;刘新超负责收集临床资料;彭斌、朱以诚、崔丽英负责审核;姚明负责分析临床资料,修改、校对。
    利益冲突  无
  • 图  1  头颅MRI T2WI(A)、T1WI(B)和T1增强矢状位(C)示小脑轻度萎缩

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出版历程
  • 收稿日期:  2018-10-30
  • 录用日期:  2019-06-10
  • 网络出版日期:  2020-06-26
  • 刊出日期:  2021-01-30

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