Research progress on pathogenesis and treatment of juvenile localized scleroderma
摘要: 青少年局限性硬皮病（JLS）是一种罕见的儿童自身免疫性疾病，早期缺乏特异性症状，易被误诊、漏诊而导致病变加剧，甚至造成机体功能损害和生长障碍等严重后果。为了明确JLS的病因，从而指导有效治疗药物的开发及应用，本文综述近年有关JLS发病机制的相关学说，归纳总结传统治疗方案及相关新型药物，旨在对JLS及其治疗进展有更深一步的认知。Abstract: Juvenile localized scleroderma (JLS) is a rare autoimmune disease in children. The lack of specificity in the early symptoms of JLS makes it easy to be misdiagnosed and missed, leading to the continuous progression of the lesions, and even causing the body function damage and growth disorder. For identifying the etiology of JLS and guiding the development and application of effective therapeutic drugs, recent theories about the pathogenesis of JLS have been reviewed, as well as the traditional treatment options and relevant new therapeutic drugs have been summarized, aiming to further enhance the fundamental understanding of JLS and its therapeutic progress.
- Juvenile localized scleroderma /
- pathogenesis /
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