Abstract: Pulmonary thromboembolism（PTE）is the third most common cause of cardiovascular death. The management of PTE emphasizes early identification, risk stratification and appropriate treatment. However, only about 20% to 30% of patients with high-risk PTE received systemic thrombolysis in the real world, due to concerns about the risks like major bleeding. Although systemic thrombolysis could decrease all-cause mortality of patients with intermediate-risk PTE, the risk of bleeding outweighs benefits. Therefore, a new thrombolytic treatment with good efficacy and safety records is stilled needed. Ultrasound-assisted catheter-directed thrombolysis could directly deliver thrombolytic drugs to the thrombus with lower dose needed. Moreover, numerous studies have demonstrated that ultrasound could enhance thrombolysis. There has been accumulating evidence on the efficacy and safety of ultrasound-assisted catheter-directed thrombolysis for the treatment of PTE. The present review article will summarize progresses made in this area in recent years.