Advances in Ultrasound-assisted Catheter-directed Thrombolysis for the treatment of Pulmonary Thromboembolism
-
摘要: 肺血栓栓塞(Pulmonary Thromboembolism,PTE)是导致心血管死亡的第三大常见原因。对于PTE的诊治强调早期识别、进行危险分层并针对性给与治疗。但在真实世界中,由于担心出现大出血等情况,只有约20%-30%的高危PTE患者接受了系统性溶栓治疗。另外,虽然中危PTE患者接受系统性溶栓可以降低死亡率,但出血风险远超获益。所以目前临床上仍需要一种安全、有效的溶栓新手段。超声辅助的导管直接溶栓可以在血栓部位直接释放溶栓药物,所需剂量也更低,且已有大量研究表明超声波可以促进血栓溶解。目前关于超声辅助的导管直接溶栓治疗PTE的有效性与安全性已经积累了一些临床证据,故本文对该研究领域的进展做一综述。Abstract: Pulmonary thromboembolism(PTE)is the third most common cause of cardiovascular death. The management of PTE emphasizes early identification, risk stratification and appropriate treatment. However, only about 20% to 30% of patients with high-risk PTE received systemic thrombolysis in the real world, due to concerns about the risks like major bleeding. Although systemic thrombolysis could decrease all-cause mortality of patients with intermediate-risk PTE, the risk of bleeding outweighs benefits. Therefore, a new thrombolytic treatment with good efficacy and safety records is stilled needed. Ultrasound-assisted catheter-directed thrombolysis could directly deliver thrombolytic drugs to the thrombus with lower dose needed. Moreover, numerous studies have demonstrated that ultrasound could enhance thrombolysis. There has been accumulating evidence on the efficacy and safety of ultrasound-assisted catheter-directed thrombolysis for the treatment of PTE. The present review article will summarize progresses made in this area in recent years.
-
Key words:
- Pulmonary Thromboembolism /
- Thrombolysis therapy /
- Ultrasound
-

计量
- 文章访问数: 83
- HTML全文浏览量: 7
- PDF下载量: 30
- 被引次数: 0