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Volume 11 Issue 4
Jul.  2020
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2020  >  11(4): 486-491
Ya-ping LUO, Fang LI, Miao YU, Xiao-ping XING, Tai-ping ZHANG, Yu-pei ZHAO. Procedure Guideline of Glucagon-like Peptide-1 Receptor Positron Emission Tomography/Computed Tomography in Localizing Insulinoma[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(4): 486-491. doi: 10.3969/j.issn.1674-9081.2020.04.022
Citation: Ya-ping LUO, Fang LI, Miao YU, Xiao-ping XING, Tai-ping ZHANG, Yu-pei ZHAO. Procedure Guideline of Glucagon-like Peptide-1 Receptor Positron Emission Tomography/Computed Tomography in Localizing Insulinoma[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(4): 486-491. doi: 10.3969/j.issn.1674-9081.2020.04.022
shu

Procedure Guideline of Glucagon-like Peptide-1 Receptor Positron Emission Tomography/Computed Tomography in Localizing Insulinoma

doi: 10.3969/j.issn.1674-9081.2020.04.022
  • 1.

    Department of Nuclear Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China

  • 3.

    Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 4.

    Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

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  • Corresponding author: LI Fang  Tel: 86-10-69155502, E-mail:lifang@pumch.cn
  • Received Date: 2018-05-29
  • Publish Date: 2020-07-30
    Abstract
  • The diagnosis and surgical treatment of insulinoma is dependent on accurate localization with imaging modalities. Glucagon-like peptide-1 receptor (GLP-1R) imaging that targets pancreatic β cells has been highlighted for detecting insulinomas in recent years. Since the high sensitivity and specificity (se. 99%, sp. 100%) of GLP-1R imaging in localizing insulinoma, GLP-1R positron emission tomography/computed tomography (PET/CT) with 68Ga-exendin-4 is recommended to be introduced into clinical practice. This paper introduced the application of GLP-1R imaging in insulinoma, and took the GLP-1R PET/CT with 68Ga-exendin-4 as an example to elaborate the operation standard of this technique, aiming to provide a reference for clinical practice.
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