Email Alert RSS
Volume 11 Issue 4
Jul.  2020
Turn off MathJax
Article Contents
Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2020  >  11(4): 472-478
Xian-xian YUAN, Hong-bo YANG, Hui-juan ZHU, Hui PAN. Measurement and the Reference Range of Serum Insulin-like Growth Factor-1[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(4): 472-478. doi: 10.3969/j.issn.1674-9081.2020.04.020
Citation: Xian-xian YUAN, Hong-bo YANG, Hui-juan ZHU, Hui PAN. Measurement and the Reference Range of Serum Insulin-like Growth Factor-1[J]. Medical Journal of Peking Union Medical College Hospital, 2020, 11(4): 472-478. doi: 10.3969/j.issn.1674-9081.2020.04.020
shu

Measurement and the Reference Range of Serum Insulin-like Growth Factor-1

doi: 10.3969/j.issn.1674-9081.2020.04.020
  • 1.

    Department of Endocrinology, Key Laboratory of Endocrinology, National Health Commission of the People's Republic of China, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    The Translational Medicine Center, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

More Information
  • Corresponding author: PAN Hui  Tel: 86-10-69155685, E-mail:panhui20111111@163.com
  • Received Date: 2018-09-26
  • Publish Date: 2020-07-30
    Abstract
  • Insulin-like growth factor-1(IGF-1) mediates the growth-promoting effect of growth hormone on peripheral tissues, which is mainly synthesized in the liver. In the circulation, most IGF-1 binds to specific binding proteins, which is more stable than growth hormone. Therefore, IGF-1 is commonly used as a diagnostic marker and treatment monitor of growth hormone deficiency and acromegaly. There are many kinds of assays that measure serum IGF-1 concentrations, including radioimmunoassay, ELISA, chemiluminescence, and mass spectrometry. Different methods have their advantages and disadvantages, so it is necessary to select the best method according to the purpose of detection. The normal reference range of IGF-1 should be established based on a random sampling of the background population. Some European and Asian countries such as Germany, Italy, Japan, and South Korea have established reference ranges of serum IGF-1 based on their own population. ZHU Hui-juan et al. from Peking Union Medical College Hospital preliminarily established the reference range of serum IGF-1 of Han Chinese adults, laying a foundation for the diagnosis and treatment of acromegaly, growth hormone deficiency, and other diseases.
    • FullText(HTML)
  • loading
    • References(48)
  • [1] Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor Ⅰ and its structural homology with proinsulin[J]. J Biol Chem, 1978, 253:2769-2776. http://europepmc.org/abstract/MED/632300
    [2] Salmon WJ, Daughaday WH. A hormonally controlled serum factor which stimulates sulfate incorporation by cartilage in vitro[J]. J Lab Clin Med, 1957, 49:825-836. https://www.ncbi.nlm.nih.gov/pubmed/2205697
    [3] Clemmons DR. Clinical utility of measurements of insulin-like growth factor 1[J]. Nat Clin Pract Endocrinol Metab, 2006, 2:436-446. doi:  10.1038/ncpendmet0244
    [4] Clemmons DR. IGF-Ⅰ assays:current assay methodologies and their limitations[J]. Pituitary, 2007, 10:121-128. doi:  10.1007/s11102-007-0032-z
    [5] Grimberg A, Divall SA, Polychronakos C, et al. Guide-lines for Growth Hormone and Insulin-Like Growth Factor-Ⅰ Treatment in Children and Adolescents:Growth Hormone Deficiency, Idiopathic Short Stature, and Primary Insulin-Like Growth Factor-Ⅰ Deficiency[J]. Horm Res Paediatr, 2016, 86:361-397. doi:  10.1159/000452150
    [6] Granada ML. Biochemical following-up of treated acrome-galy. Limitations of the current determinations of IGF-1 and perspective[J]. Minerva Endocrinol, 2019, 44:143-158.
    [7] Skjaerbaek C, Frystyk J, Orskov H, et al. Differential changes in free and total insulin-like growth factor Ⅰ after major, elective abdominal surgery:the possible role of insulin-like growth factor-binding protein-3 proteolysis[J]. J Clin Endocrinol Meta, 1998, 83:2445-2449. https://www.ncbi.nlm.nih.gov/pubmed/9661626
    [8] Lang CH, Fan J, Frost RA, et al. Regulation of the insulin-like growth factor system by insulin in burn patients[J]. J Clin Endocrinol Metab, 1996, 81:2474-2480. http://www.ncbi.nlm.nih.gov/pubmed/8675563
    [9] Congote LF. Monitoring insulin-like growth factors in HIV infection and AIDS[J]. Clin Chim Acta, 2005, 361:30-53. doi:  10.1016/j.cccn.2005.05.001
    [10] Nimptsch K, Pischon T. Obesity Biomarkers, Metabolism and Risk of Cancer:An Epidemiological Perspective[J]. Recent Results Cancer Res, 2016, 208:199-217.
    [11] Tas F, Bilgin E, Tastekin D, et al. Serum IGF-1 and IGFBP-3 levels as clinical markers for patients with lung cancer[J]. Biomed Rep, 2016, 4:609-614. doi:  10.3892/br.2016.629
    [12] Rainato G, Fabricio AS, Zancan M, et al. Evaluating serum insulin-like growth factor 1 and insulin-like growth factor binding protein 3 as markers in prostate cancer diagnosis[J]. Int J Biol Markers, 2016, 31:e317-e323. doi:  10.5301/jbm.5000200
    [13] Liu S, Liu Y, Jiang X. Prognostic significance of serum insulin-like growth factor-1 in patients with hepatocellular carcinoma following transarterial chemoembolization[J]. Exp Ther Med, 2016, 11:607-612. doi:  10.3892/etm.2015.2949
    [14] Morgillo F, De Vita F, Antoniol G, et al. Serum insulin-like growth factor 1 correlates with the risk of nodal metastasis in endocrine-positive breast cancer[J]. Curr Oncol, 2013, 20:e283-e288. doi:  10.3747/co.20.1380
    [15] 杜伟, 李芸, 毛笑非, 等.胰岛素样生长因子与系统性硬皮病的相关性[J].协和医学杂志, 2012, 3:370-374. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=xhyx201204002
    [16] Furlanetto RW, Underwood LE, Van Wyk JJ, et al. Estimation of somatomedin-C levels in normals and patients with pituitary disease by radioimmunoassay[J]. J Clin Invest, 1977, 60:648-657. doi:  10.1172/JCI108816
    [17] Frystyk J, Freda P, Clemmons DR. The current status of IGF-Ⅰ assays-a 2009 update[J]. Growth Horm IGF Res, 2010, 20:8-18. doi:  10.1016/j.ghir.2009.09.004
    [18] Burns C, Rigsby P, Moore M, et al. The First International Standard For Insulin-like Growth Factor-1(IGF-1) for immunoassay:preparation and calibration in an international collaborative study[J]. Growth Horm IGF Res, 2009, 19:457-462. doi:  10.1016/j.ghir.2009.02.002
    [19] Daughaday WH, Kapadia M, Mariz I. Serum somatomedin binding proteins:physiologic significance and interference in radioligand assay[J]. J Lab Clin Med, 1987, 109:355-363. http://www.ncbi.nlm.nih.gov/pubmed/2434590
    [20] Nelson RW, Nedelkov D, Tubbs KA, et al. Quantitative mass spectrometric immunoassay of insulin like growth factor 1[J]. J Proteome Res, 2004, 3:851-855. doi:  10.1021/pr0499388
    [21] Bystrom C, Sheng S, Zhang K, et al. Clinical utility of insulin-like growth factor 1 and 2; determination by high resolution mass spectrometry[J]. PLoS One, 2012, 7:e43457. doi:  10.1371/journal.pone.0043457
    [22] Cox HD, Lopes F, Woldemariam GA, et al. Interlabora-tory agreement of insulin-like growth factor 1 concentrations measured by mass spectrometry[J]. Clin Chem, 2014, 60:541-548. doi:  10.1373/clinchem.2013.208538
    [23] Juul A. Serum levels of insulin-like growth factor Ⅰ and its binding proteins in health and disease[J]. Growth Horm IGF Res, 2003, 13:113-170. doi:  10.1016/S1096-6374(03)00038-8
    [24] Peters CJ, Dattani MT. How to use insulin-like growth factor 1(IGF1)[J]. Arch Dis Child Educ Pract Ed, 2012, 97:114-118. doi:  10.1136/archdischild-2011-300265
    [25] Brabant G, von Zur MA, Wuster C, et al. Serum insulin-like growth factor Ⅰ reference values for an automated chemiluminescence immunoassay system:results from a multi-center study[J]. Horm Res, 2003, 60:53-60. http://onlinelibrary.wiley.com/resolve/reference/XREF?id=10.1159/000071871
    [26] Clemmons DR. Consensus statement on the standardization and evaluation of growth hormone and insulin-like growth factor assays[J]. Clin Chem, 2011, 57:555-559. doi:  10.1373/clinchem.2010.150631
    [27] Zapf J, Walter H, Froesch ER. Radioimmunological determination of insulinlike growth factors Ⅰ and Ⅱ in normal subjects and in patients with growth disorders and extrapancrea-tic tumor hypoglycemia[J]. J Clin Invest, 1981, 68:1321-1330. doi:  10.1172/JCI110379
    [28] Inoue T, Watanabe N. Studies on plasma insulin-like growth factor (IGF)-Ⅰ levels in normal subjects and in patients with various endocrine and metabolic diseases using radioimmunoassay for synthetic IGF-Ⅰ (26-46)[J]. Nihon Naibunpi Gakkai Zasshi, 1986, 62:45-59. http://www.onacademic.com/detail/journal_1000039709857910_827f.html
    [29] 刘蓉, 史轶繁, 邓洁英, 等.中国正常儿童和青少年血清生长介素水平[J].中华儿科杂志, 1989, 27:330-334. http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zhek19890605092
    [30] Juul A, Bang P, Hertel NT, et al. Serum insulin-like growth factor-Ⅰ in 1030 healthy children, adolescents, and adults:relation to age, sex, stage of puberty, testicular size, and body mass index[J]. J Clin Endocrinol Metab, 1994, 78:744-752.
    [31] Juul A, Dalgaard P, Blum WF, et al. Serum levels of insulin-like growth factor (IGF)-binding protein-3(IGFBP-3) in healthy infants, children, and adolescents:the relation to IGF-Ⅰ, IGF-Ⅱ, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation[J]. J Clin Endocrinol Metab, 1995, 80:2534-2542. http://www.ncbi.nlm.nih.gov/pubmed/7543116
    [32] 徐源.中国正常成人血清IGF-1的参考范围及其影响因素研究[D].北京: 中国医学科学院北京协和医学院, 2016.
    [33] Isojima T, Shimatsu A, Yokoya S, et al. Standardized centile curves and reference intervals of serum insulin-like growth factor-I (IGF-I) levels in a normal Japanese population using the LMS method[J]. Endocr J, 2012, 59:771-780. doi:  10.1507/endocrj.EJ12-0110
    [34] Hyun SE, Lee BC, Suh BK, et al. Reference values for serum levels of insulin-like growth factor-Ⅰ and insulin-like growth factor binding protein-3 in Korean children and adolescents[J]. Clin Biochem, 2012, 45:16-21. doi:  10.1016/j.clinbiochem.2011.10.003
    [35] Plengpanich W, Mangkala J, Buranasukajorn P, et al. Normal reference range of serum insulin-like growth factor (IGF)-Ⅰ in healthy Thai adults[J]. J Med Assoc Thai, 2008, 91:1681-1684. http://www.ncbi.nlm.nih.gov/pubmed/19127789
    [36] Kong AP, Wong GW, Choi KC, et al. Reference values for serum levels of insulin-like growth factor (IGF-1) and IGF-binding protein 3(IGFBP-3) and their ratio in Chinese adolescents[J]. Clin Biochem, 2007, 40:1093-1099. doi:  10.1016/j.clinbiochem.2007.06.004
    [37] Xu S, Gu X, Pan H, et al. Reference ranges for serum IGF-1 and IGFBP-3 levels in Chinese children during childhood and adolescence[J]. Endocr J, 2010, 57:221-228. doi:  10.1507/endocrj.K09E-200
    [38] 崔立全.乌鲁木齐市汉族健康成人IGF-1的血清浓度测定[D].乌鲁木齐: 新疆医科大学, 2011.
    [39] Zhu H, Xu Y, Gong F, et al. Reference ranges for serum insulin-like growth factor Ⅰ (IGF-Ⅰ) in healthy Chinese adults[J]. PLoS One, 2017, 12:e185561.
    [40] Leung KC, Johannsson G, Leong GM, et al. Estrogen regulation of growth hormone action[J]. Endocr Rev, 2004, 25:693-721. doi:  10.1210/er.2003-0035
    [41] Elkazaz AY, Salama K. The effect of oral contraceptive different patterns of use on circulating IGF-1 and bone mineral density in healthy premenopausal women[J]. Endocrine, 2015, 48:272-278. doi:  10.1007/s12020-014-0290-2
    [42] Wang C. Trends in contraceptive use and determinants of choice in China:1980-2010[J]. Contraception, 2012, 85:570-579. doi:  10.1016/j.contraception.2011.10.014
    [43] Friedrich N, Alte D, Volzke H, et al. Reference ranges of serum IGF-1 and IGFBP-3 levels in a general adult population:results of the Study of Health in Pomerania (SHIP)[J]. Growth Horm IGF Res, 2008, 18:228-237. doi:  10.1016/j.ghir.2007.09.005
    [44] Rosario PW. Normal values of serum IGF-1 in adults:results from a Brazilian population[J]. Arq Bras Endocrinol Metabol, 2010, 54:477-481. doi:  10.1590/S0004-27302010000500008
    [45] Scacchi M, Pincelli AI, Cavagnini F. Growth hormone in obesity[J]. Int J Obes Relat Metab Disord, 1999, 23:260-271. doi:  10.1038/sj.ijo.0800807
    [46] Bayram F, Gedik VT, Demir O, et al. Epidemiologic survey:reference ranges of serum insulin-like growth factor 1 levels in Caucasian adult population with immunoradiometric assay[J]. Endocrine, 2011, 40:304-309. doi:  10.1007/s12020-011-9476-z
    [47] Hong Y, Brismar K, Hall K, et al. Associations between insulin-like growth factor-I (IGF-I), IGF-binding protein-1, insulin and other metabolic measures after controlling for genetic influences:results from middle-aged and elderly monozygotic twins[J]. J Endocrinol, 1997, 153:251-257. doi:  10.1677/joe.0.1530251
    [48] Chen J, Zheng H, Bei JX, et al. Genetic structure of the Han Chinese population revealed by genome-wide SNP variation[J]. Am J Hum Genet, 2009, 85:775-785. doi:  10.1016/j.ajhg.2009.10.016
    • Relative Articles(0)
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Tables(2)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (3676) PDF downloads(486) Cited by()
    Proportional views
    Related
    Links: National Health Commission of the People's Republic of China Chinese Academy of Medical Sciences(CAMS) AMLC Check CNKI Database CNKI Term Online Chinese General Practice
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn
    mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return