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Volume 12 Issue 4
Jul.  2021
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2021  >  12(4): 531-536
LIU Qiaofei, LIAO Quan. Immunoglobulin G4 and Malignant Tumors[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(4): 531-536. doi: 10.3969/j.issn.1674-9081.2020.00.022
Citation: LIU Qiaofei, LIAO Quan. Immunoglobulin G4 and Malignant Tumors[J]. Medical Journal of Peking Union Medical College Hospital, 2021, 12(4): 531-536. doi: 10.3969/j.issn.1674-9081.2020.00.022
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Immunoglobulin G4 and Malignant Tumors

doi: 10.3969/j.issn.1674-9081.2020.00.022

  • Department of General Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

National Natural Science Foundation of China 81560387

National Natural Science Foundation of China 81673023

National Natural Science Foundation of China 81872501

National Natural Science Foundation of China 81502068

National Natural Science Foundation of China 81272573

Beijing Natural Science Foundation 7172177

More Information
  • Corresponding author: LIAO Quan Tel：86-10-69152600，E-mail：lqpumc@126.com
  • Received Date: 2020-01-15
  • Accepted Date: 2020-08-20
    • Available Online: 2020-12-16
  • Publish Date: 2021-07-30
    Abstract
  • Abnormal elevation of serum immunoglobulin G4 (IgG4) and abundant infiltration of IgG4-positive plasma cells in diseased tissues are the most common clinicopathological features of IgG4-related disease (IgG4-RD). It can affect almost any tissue and organ, and has a variety of clinical manifestations. Increasing studies have found that as a member of IgG family that negatively regulates immune response, IgG4 is correlated with the occurrence and prognosis of malignant tumors and with tumor immunity. This paper reviewed the relationship between IgG4 and malignant tumors and the role of IgG4 in tumor immunity.
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