Objective This study was to investigate the antibiotic resistance profile of clinically important bacteria that World Health Organization(WHO) is concerned about, in Peking Union Medical College Hospital(PUMCH) from January 1, 2007 to December 31, 2016.
Methods Disc diffusion test (Kirby-Bauer method) and automated systems were employed to detect antibiotic resistance. Data were analyzed by WHONET 5.6 software according to the 2016 edition of antbioticl susceptibility testing standards issued by the Clinical and Laboratory Standards Institute (CLSI) of the United States.
Results A total of 46 168 non-duplicated main clinical isolates were collected in PUMCH from 2007 to 2016, including 6679 strains of Pseudomonas aeruginosa, 6422 strains of Acinetobacter baumannii, 24 001 strains of Enterobacteriaceae (11 046 strains of Escherichia coli and 6034 strains of Klebsiella pneumonia), 2358 strains of Enterococcus faecium, 6056 strains of Staphylococcus aureus, 652 strains of Streptococcus pneumonia, and 999 strains of Haemophilus influenza. Based on the surveillance data during the 10 years, we found that, the detection rate of the carbapenem-resistant P. aeruginosa decreased from 38.3% in 2007 to 22.4% in 2016; the detection rate of carbapenem-resistant A. baumannii increased from 52.8% in 2007 to 71.9% in 2016; the imipenem-resistance rate of K.pneumonia increased from 1.3% in 2007 to 14.4% in 2016. The vancomycin-resistance rate of E. faecium was 3.3%-5.8% in recent 5 years. The detection rate of Methicillin-resistant S. aureus (MRSA) decreased from 56.5% in 2007 to 27.0% in 2016. The detection rate of penicillin-insensitive S.pneumonia was 0.9%-6.4% in recent 2 years.
Conclusions The prevalence of carbapenem-resistant K.pneumoniae and A.baumannii is still increasing. Carbapenem-resistant strains pose a huge challenge for anti-infection therapy.
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