Progress in Research on MicroRNA in Tuberous Sclerosis Complex Related Diseases

Tuberous sclerosis complex(TSC) is an autosomal dominant genetic disease involving multiple organs and systems. It can involve all organs and systems in the body. Nodular sclerosis is often manifested as skin lesions and visceral benign tumors, as well as a small number of highly malignant tumors, such as subependymal giant cell astrocytoma(SEGA), renal cell carcinoma and so on. There is growing evidence that microRNAs(miRNAs) are closely related to TSC related diseases and act as oncogenes or tumor suppressor genes. This paper reviews the progress of study on miRNA in several diseases related to tuberous sclerosis complex.