Angiotensin Ⅱ in Predicting the In-hospital Prognosis of Patients Undergoing Elective Percutaneous Coronary Intervention

  Objective  To investigate the effect of angiotensin Ⅱ in predicting the in-hospital prognosis of patients who received elective percutaneous coronary intervention.

  Methods  From July 2012 to July 2013, 645 consecutive patients receiving elective percutaneous coronary intervention in Department of Cardiology in Peking Union Medical College Hospital were selected. Plasma level of angiotensin Ⅱ was measured in these patients, and in-hospital adverse cardiac events (including all-cause death, nonfatal myocardial infarction, new nonfatal ischemic stroke, new nonfatal hemorrhagic stroke, and unplanned vessel revascularization) were recorded. The relationship between angiotensin Ⅱ level and incidence of in-hospital adverse cardiac events was analyzed.

  Results  Among the 645 patients, 68 (10.54%) developed in-hospital adverse cardiac events. Plasma level of angiotensin Ⅱ was significantly higher in the patients who had in-hospital adverse cardiac events compared with those who did not41.42 (28.73, 57.07)ng/L vs. 35.66 (22.84, 48.22)ng/L, P=0.009. Multivariate logistic regression analysis showed that plasma level of angiotensin Ⅱ was an independent risk factor of in-hospital adverse cardiac events (OR 1.018, 95% CI:1.004~1.032, P=0.012).

  Conclusion  Plasma level of angiotensin Ⅱ may be correlated with poor in-hospital prognosis of patients who received elective percutaneous coronary intervention, hence it may have important predictive value.