Objective To investigate the risk factors for neutropenia in extremely low birth weight (ELBW) infants.
Methods We retrospectively studied the clinical data of ELBW infants treated in Neonatal Intensive Care Unit of Peking Union Medical College Hospital between January 2011 and December 2013. They were divided into two groups according to the presence or absence of neutropenia within the first postnatal week (early-onset or non-early-onset neutropenia), also divided into two groups according to the presence or absence of neutropenia after a week (late-onset or non-late-onset neutropenia). The clinical characteristics were compared between groups to identify possible risk factors for neutropenia.
Results One hundred and eight infants were included. Their mean gestational age was (30.1±2.2)weeks, and mean birth weight was (1188±216)g. Among them, 32 had early-onset neutropenia, and 53 had late-onset neutropenia. The incidence of gestational hypertension was significantly higher in mothers of the infants with early-onset neutropenia than in those of the infants with non-early-onset neutropenia (59.4% vs. 31.6%, P=0.007). Compared with infants with non-late-onset neutropenia, the gestational age was smaller and birth weight was lower in infants with late-onset neutropenia (29.5±2.3) weeks vs. (30.6±2.0) weeks, P=0.009; (1123±212)g vs. (1251±201)g, P=0.002, while the incidences of early-onset infection and late-onset infection were higher in infants with late-onset neutropenia (50.9% vs. 30.9%, P=0.034; 100% vs. 43.6%, P < 0.001). Among the infants with early-onset infection, the incidence of thrombocytopenia was higher than that of neutropenia (45.5% vs. 25.0%, P=0.045).
Conclusions The risk factors for early-onset neutropenia and late-onset neutropenia are different, of which the former may include gestational hypertension, while the latter may include small gestational age, low birth weight, early-onset infection, and late-onset infection.
Email Alert
RSS
DownLoad: