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Jie SHEN, Yue MING, Xian-chao TANG, Ke HU, Zhi-kai LIU, Xian-song SUN, Wen-bo LI, Zhi-wei YANG, Fei JIANG, Nan LI, Li-min LI, Fu-quan ZHANG. Radiosensitivity of Cervical Cancer Cells to Different Radiation Doses and Dose Rates[J]. Medical Journal of Peking Union Medical College Hospital, 2013, 4(4): 383-386. DOI: 10.3969/j.issn.1674-9081.2013.04.008
Citation: Jie SHEN, Yue MING, Xian-chao TANG, Ke HU, Zhi-kai LIU, Xian-song SUN, Wen-bo LI, Zhi-wei YANG, Fei JIANG, Nan LI, Li-min LI, Fu-quan ZHANG. Radiosensitivity of Cervical Cancer Cells to Different Radiation Doses and Dose Rates[J]. Medical Journal of Peking Union Medical College Hospital, 2013, 4(4): 383-386. DOI: 10.3969/j.issn.1674-9081.2013.04.008
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Radiosensitivity of Cervical Cancer Cells to Different Radiation Doses and Dose Rates

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    • Abstract
  •   Objective  To explore the radiosensitivity of different types of cervical cancer cells to different radiation doses and dose rates.
      Methods  We established three cell radiosensitivity models with three cervical cancer cell lines:CaSki, HeLa, and SiHa. We then used clonogenic assay to analyze the radiosensitivity of these three cell lines to different radiation doses and dose rates.
      Results  The survival fractions at 2 Gy (SF2) were 57.37%, 70.62%, and 74.77% for CaSki, HeLa, and SiHa, respectively (P=0.002). However, the survival fractions did not significantly differ when the three cell lines were treated with dose rates of 200, 400, and 600 cGy/min (P > 0.05).
      Conclusions  Among these three cell lines, CaSki has the highest radiosensitivity, followed by HeLa and SiHa. The dose rate used in our experiment showed no effect on the the survival fraction of three cervical cancer cell lines.
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