Objective To compare the effectiveness, cost, and quality of life between loop electrosurgical excision procedure(LEEP)and CO2 laser vaporization in treating cervical intraepithelial neoplasia 2(CIN2).
Methods Totally 338 women with colposcopic-histopathologically confirmed CIN2 were enrolled in this study, of whom 195 underwent LEEP(LEEP group)and 143 underwent CO2 laser vaporization(laser group).They were followed up 3, 6, and 12 months after treatment.A questionnaire of EORTC QLQ-C30 and QLQ-CX24 were filled out at 12 months follow-up.
Results In LEEP group, CIN was cured in 174 patients(89.2%)and relapsed in 7(3.6%).In laser group, CIN was cured in 124 patients(86.7%)and relapsed in 1 patient(0.70%)(both P > 0.05).The recovery time, number of operation, bleeding volume, and costs were significantly different between these two groups(P < 0.05).Women treated with LEEP showed relatively identical quality of life compared with those treated with CO2 laser vaporization.
Conclusions Both LEEP and CO2 laser vaporization are effective and reliable for the treatment of CIN2, while pre-operative evaluations and post-operative follow-up are essential.Attention should also be paid to the post-operative quality of life.
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