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Volume 2 Issue 1
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2011  >  2(1): 7-14
Ya-li XU, Qiang SUN, Guang-liang SHAN, Jin Zhang, Hai-bo Liao, Shi-yong Li, Jun JIANG, Zhi-min Shao, Hong-chuan JIANG, Nian-chun SHEN, Yue SHI, Cheng-ze YU, Bao-ning ZHANG, Yan-hua CHEN, Xue-ning DUAN, Bo LI. Risk Factors of Breast Cancer in China: A Case-Control Study[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(1): 7-14. doi: 10.3969/j.issn.1674-9081.2011.01.002
Citation: Ya-li XU, Qiang SUN, Guang-liang SHAN, Jin Zhang, Hai-bo Liao, Shi-yong Li, Jun JIANG, Zhi-min Shao, Hong-chuan JIANG, Nian-chun SHEN, Yue SHI, Cheng-ze YU, Bao-ning ZHANG, Yan-hua CHEN, Xue-ning DUAN, Bo LI. Risk Factors of Breast Cancer in China: A Case-Control Study[J]. Medical Journal of Peking Union Medical College Hospital, 2011, 2(1): 7-14. doi: 10.3969/j.issn.1674-9081.2011.01.002
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Risk Factors of Breast Cancer in China: A Case-Control Study

doi: 10.3969/j.issn.1674-9081.2011.01.002
  • 1.

    Department of Breast Surgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Epidemiology and Statistics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100005, China

  • 3.

    The 3rd Department of Breast Neoplasm, Cancer Hospital, Tianjin Medical University, Tianjin 300060, China

  • 4.

    Treatment Center of Breast Disease, Yingbin Surgery Hospital, Yancheng 224005, China

  • 5.

    Department of General Surgery, General Hospital affiliated to Beijing Military Area Command, Beijing 100700, China

  • 6.

    Department of Breast Surgery, Affiliated Southwest Hospital, Third Military Medical University, Chongqing 400038, China

  • 7.

    Department of Breast Surgery, Affiliated Cancer Hospital, Fudan University, Shanghai 200032, China

  • 8.

    Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China

  • 9.

    Population and Family Planning Service Center of Zhuhai, Zhuhai 519100, China

  • 10.

    Department of Breast Disease, Shanxi Traditional Medicine Hospital, Taiyuan 030012, China

  • 11.

    Department of General Surgery, Chinese 307 Hospital affiliated to the People's Liberation Army, Beijing 100071, China

  • 12.

    Department of Abdominal Surgery, Cancer Institute & Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China

  • 13.

    Department of Breast Disease, Maternity & Child Care Center of Qinhuangdao, Qinhuangdao 066000, China

  • 14.

    Department of General Surgery, First Hospital, Peking University, Beijing 100034, China

  • 15.

    Department of General Surgery, Beijing Hospital, Ministry of Health, Beijing 100730, China

More Information
  • Corresponding author: SUN Qiang Tel:010-88068140, E-mail:pumchsunqiang@126.com
  • Received Date: 2010-10-11
  • Publish Date: 2011-01-30
    Abstract
  •   Objective  To screen the risk factors associated with breast cancer among Chinese women, with an attempt to provide evidence for the evaluation of breast cancer risks among Chinese women on an individual level.  Methods  A case-control study on 416 breast cancer patients and 1156 age-and region-matched controls was conducted in 14 hospitals in 8 provinces/municipalities of China.Conditional logistic regression was applied to analyze the association between risk factors and breast cancer.  Results  The risk factors of breast cancer among Chinese women included higher body mass index(BMI ≥ 24)(OR=4.07, 95%CI:2.98-5.55), history of benign breast disease biopsy(OR=1.68, 95%CI:1.19-2.38), age of menarche ≥ 14 years(OR=1.41, 95%CI:1.07-1.87), psychological depression(for grade 1-4, OR=2.15, 95% CI:1.26-3.66;for grade 5-9, OR=3.48, 95% CI:2.03-5.95), menostasia(OR=2.22, 95% CI:1.50-3.28), family history of breast cancer(OR=1.72, 95%CI:1.15-2.58), and family history of cancer other than breast cancer(OR=1.55, 95%CI:1.22~1.98)(all P < 0.05 when compared between the 416 breast cancer patients and 1156 controls).Although use of oral contraceptives(OC)(OR=1.59, 95% CI:0.83-3.05)was associated with an increased risk of breast cancer, the difference was not statistically significant(P > 0.05).  Conclusions  Many risk factors including BMI ≥ 24, history of benign breast disease biopsy, age of menarche ≥ 14 years, psychological depression, menostasia, family history of breast cancer, and family history of cancer other than breast cancer may contribute to breast cancer among Chinese women.This research provides a basis for the individualized evaluation of risks of breast cancer and the population-based interventions in China.
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