ZHANG Xin, ZHANG Xiao, GUO Yi, FENG Jun, XIAO Zhiyuan, XIE Zhaoxiang, WU Jing, XU Dongrui, WEI Junji, WANG Yu. Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 217-222. DOI: 10.12290/xhyxzz.2023-0377
Citation: ZHANG Xin, ZHANG Xiao, GUO Yi, FENG Jun, XIAO Zhiyuan, XIE Zhaoxiang, WU Jing, XU Dongrui, WEI Junji, WANG Yu. Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation[J]. Medical Journal of Peking Union Medical College Hospital, 2024, 15(1): 217-222. DOI: 10.12290/xhyxzz.2023-0377

Successful Treatment of A Patient with Chronic Myeloid Leukemia Complicated by Cerebral Hemorrhage Manifesting as Platelet Abnormal Elevation

  • Platelet elevation is a rare manifestation in the peripheral blood of patients with chronic myeloid leukemia (CML). In this paper, we report for the first time a case of CML combined with cerebral hemorrhage manifested by abnormally elevated platelets. The patient had elevated platelets in the peripheral blood, showed normal coagulation function, and underwent intracranial hematoma removal due to cerebral hemorrhage. After the operation, bleeding from the operated area and other systems occurred, and the patient was diagnosed as having accelerated CML after combining bone marrow biopsy and genetic testing. His condition was controlled after administration of flumatinib through a jejunal tube. Based on this patient's experience, the feasibility ofadministering flumatinib via a jejunostomy tube was determined, which is the first report of its kind in China and abroad.This article summarizes the diagnosis and treatment process of this patient, with the aim of providing a warning and reference for clinicians.
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