BAI Xiaoyin, YANG Hong. Interpretation of Guidance for the Design and Implementation of Drug Clinical Studies: Based on E8 (R1): General Considerations for Clinical Trials[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 81-85. doi: 10.12290/xhyxzz.2022-0611
Citation:
BAI Xiaoyin, YANG Hong. Interpretation of Guidance for the Design and Implementation of Drug Clinical Studies: Based on E8 (R1): General Considerations for Clinical Trials[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 81-85. doi: 10.12290/xhyxzz.2022-0611
BAI Xiaoyin, YANG Hong. Interpretation of Guidance for the Design and Implementation of Drug Clinical Studies: Based on E8 (R1): General Considerations for Clinical Trials[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 81-85. doi: 10.12290/xhyxzz.2022-0611
Citation:
BAI Xiaoyin, YANG Hong. Interpretation of Guidance for the Design and Implementation of Drug Clinical Studies: Based on E8 (R1): General Considerations for Clinical Trials[J]. Medical Journal of Peking Union Medical College Hospital, 2023, 14(1): 81-85. doi: 10.12290/xhyxzz.2022-0611
Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
Funds:
National High Level Hospital Clinical Research Funding2022-PUMCH-C-018
National High Level Hospital Clinical Research Funding2022-PUMCH-A-074
As clinical research and drug development in China continue to advance, greater attention has been paid to the value of clinical research guidelines. The first revision of the original E8 recommendations (R1), "General Considerations for Clinical Research" was made by the International Council for Harmonization in October 2021. Our National Medical Products Administration has recently opted to implement the rules beginning from July 2023. In order to provide useful references for improved design and execution of drug clinical studies in China, this paper primarily interprets the fundamental background and revision of E8 (R1) from the perspective of clinical workers. It also analyzes and discusses the application of the current clinical study guidelines in China.
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