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Volume 13 Issue 6
Nov.  2022
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2022  >  13(6): 948-952
HE Liyun, ZHANG Huabing, LI Yuxiu. Comprehensive Assessment and Rational Decision-making: Based on Recent FindingsAbout Safety of Glucagon-like Peptide-1 Receptor Agonists[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 948-952. doi: 10.12290/xhyxzz.2022-0391
Citation: HE Liyun, ZHANG Huabing, LI Yuxiu. Comprehensive Assessment and Rational Decision-making: Based on Recent FindingsAbout Safety of Glucagon-like Peptide-1 Receptor Agonists[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 948-952. doi: 10.12290/xhyxzz.2022-0391
shu

Comprehensive Assessment and Rational Decision-making: Based on Recent FindingsAbout Safety of Glucagon-like Peptide-1 Receptor Agonists

doi: 10.12290/xhyxzz.2022-0391

  • Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

Beijing Natural Science Foundation M22014

CAMS Innovation Fund for Medical Sciences 2021-1-I2M-002

More Information
  • Corresponding author: ZHANG Huabing, E-mail: huabingzhangchn@163.com
  • Received Date: 2022-07-14
  • Accepted Date: 2022-08-29
    • Available Online: 2022-09-27
  • Publish Date: 2022-11-30
    Abstract
  • Glucagon-like peptide-1 receptor agonists (GLP-1RAs), as a kind of novel hypoglycemic agent, are widely used in patients with type 2 diabetes. GLP-1RAs are effective in glycemic control with low risk of hypoglycemia, significant weight loss, and cardiovascular benefit and renal protection. The most common adverse effects of GLP-1RAs are mild to moderate gastrointestinal symptoms, which generally resolve over time. The use of GLP-1RAs also increases the risk of gallbladder or biliary diseases, especially when used at higher doses, for longer durations, and for weight loss, but the absolute risk of gallbladder or biliary tract disease is small. Clinicians and patients need to carefully weigh the benefits and risks of GLP-1RAs to make decisions for the rational use of GLP-1RAs.
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