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Volume 13 Issue 5
Sep.  2022
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2022  >  13(5): 831-836
XU Haojie, DAI Yimin, TANG Kaichen, ZHONG Yilin, PANG Yiyun, WANG Lu, LI Yue, ZHAO Lidan. Investigation on the Awareness and Acceptance of Fecal Microbiota Transplantation Among Medical Students[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 831-836. doi: 10.12290/xhyxzz.2022-0175
Citation: XU Haojie, DAI Yimin, TANG Kaichen, ZHONG Yilin, PANG Yiyun, WANG Lu, LI Yue, ZHAO Lidan. Investigation on the Awareness and Acceptance of Fecal Microbiota Transplantation Among Medical Students[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 831-836. doi: 10.12290/xhyxzz.2022-0175
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Investigation on the Awareness and Acceptance of Fecal Microbiota Transplantation Among Medical Students

doi: 10.12290/xhyxzz.2022-0175
  • 1.

    Department of Rheumatology and Clinical Immunology, Ministry of Education Key Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

  • 2.

    Eight-year Program of Clinical Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tsinghua University, Beijing 100730, China

  • 3.

    Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China

Funds:

National Natural Sciences Foundation of China 81771763

National Natural Sciences Foundation of China 82071840

CAMS Innovation Fund for Medical Sciences 2020-I2M-C & T-B-013

More Information
  • Corresponding author: ZHAO Lidan, E-mail: zhaolidan@hotmail.com
  • Received Date: 2022-04-03
  • Accepted Date: 2022-08-01
    • Available Online: 2022-08-19
  • Publish Date: 2022-09-30
    Abstract
  •   Objective  To provide inspiration for the clinical application and development of fecal microbiota transplantation (FMT) by investigating the awareness and acceptance of this technology among clinical medical students of different grades.  Methods  An electronic questionnaire was used to investigate the group of eight-year medical students at Peking Union Medical College, Tsinghua University from Class 2014—2021. The students were divided into clinical medicine group (Class 2014—2016), transitional group (Class 2017—2018) and basic medicine group (Class 2019—2021) according to their grades. The awareness and acceptance of FMT among different groups of medical students were explored through data analysis and comparison between different groups.  Results  A total of 210 questionnaires were distributed and 205 valid questionnaires were recovered, with an effective recovery rate of 97.6%. There were significant differences in FMT awareness among medical students of different grades (P < 0.001). 35.6%(73/205) of the medical students did not know anything about FMT, among which the basic group had the highest proportion, compared with the clinical group and the transition group, and the difference was statistically significant(59.7% vs. 10.3%, P < 0.001; 59.7% vs. 32.0%, P=0.001). 77.1%(158/205) of medical students agreed to use FMT for disease treatment, and the proportion of clinical group(82.8%) and transition group (82.7%) was higher than that of basic group (66.7%). The main concerns of not agreeing to use FMT for the treatment of patients' diseases were "insufficient evidence of evidence-based medicine" and "fear of infection with other unknown diseases". 78.0%(160/205) agreed to use FMT for the treatment of their own diseases, and the proportions of clinical group, transition group and basic group were 77.6%, 81.3% and 75.0%, respectively. Moreover, 83.7%(169 / 202) of medical students were willing to donate their fecal microbiota for disease treatment.  Conclusions  The overall awareness of FMT among medical students is insufficient, but with the increase of years of education, the awareness continues to improve. Meanwhile, most medical students are willing to donate their fecal microbiota and accept FMT as an exploratory attempt for the treatment of patients' and their own diseases, which will help promote the development of FMT related clinical research in China. More attention should be paid to the promotion of FMT related research among medical students, in order to offer more insights and suggestions for the development and improvement of new technologies.
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    • References(17)
  • [1] Borody TJ, Khoruts A. Fecal microbiota transplantation and emerging applications[J]. Nat Rev Gastroenterol Hepatol, 2011, 9: 88-96.
    [2] Eiseman B, Silen W, Bascom GS, et al. Fecal enema as an adjunct in the treatment of pseudomembranous enterocolitis[J]. Surgery, 1958, 44: 854-859.
    [3] van Nood E, Vrieze A, Nieuwdorp M, et al. Duodenal infusion of donor feces for recurrent Clostridium difficile[J]. N Engl J Med, 2013, 368: 407-415. doi:  10.1056/NEJMoa1205037
    [4] Surawicz CM, Brandt LJ, Binion DG, et al. Guidelines for diagnosis, treatment, and prevention of Clostridium difficile infections[J]. Am J Gastroenterol, 2013, 108: 478-498;quiz 499. doi:  10.1038/ajg.2013.4
    [5] Bennet JD, Brinkman M. Treatment of ulcerative colitis by implantation of normal colonic flora[J]. Lancet, 1989, 1: 164.
    [6] Borody TJ, George L, Andrews P, et al. Bowel-flora alteration: a potential cure for inflammatory bowel disease and irritable bowel syndrome?[J]. Med J Aust, 1989, 150: 604.
    [7] Paramsothy S, Walsh AJ, Borody T, et al. Gastroentero-logist perceptions of faecal microbiota transplantation[J]. World J Gastroenterol, 2015, 21: 10907-10914. doi:  10.3748/wjg.v21.i38.10907
    [8] El-Salhy M, Hatlebakk JG, Hausken T. Diet in Irritable Bowel Syndrome(IBS): Interaction with Gut Microbiota and Gut Hormones[J]. Nutrients, 2019, 11: 1824. doi:  10.3390/nu11081824
    [9] Rinott E, Youngster I, Yaskolka Meir A, et al. Effects of Diet-Modulated Autologous Fecal Microbiota Transplantation on Weight Regain[J]. Gastroenterology, 2021, 160: 158-173. e110. doi:  10.1053/j.gastro.2020.08.041
    [10] Davar D, Dzutsev AK, McCulloch JA, et al. Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients[J]. Science, 2021, 371: 595-602. doi:  10.1126/science.abf3363
    [11] Ding X, Li Q, Li P, et al. Fecal microbiota transplantation: A promising treatment for radiation enteritis?[J]. Radiother Oncol, 2020, 143: 12-18. doi:  10.1016/j.radonc.2020.01.011
    [12] Zipursky JS, Sidorsky TI, Freedman CA, et al. Patient attitudes toward the use of fecal microbiota transplantation in the treatment of recurrent Clostridium difficile infection[J]. Clin Infect Dis, 2012, 55: 1652-1658. doi:  10.1093/cid/cis809
    [13] Zeitz J, Bissig M, Barthel C, et al. Patients' views on fecal microbiota transplantation: an acceptable therapeutic option in inflammatory bowel disease? [J]. Eur J Gastroenterol Hepatol, 2017, 29: 322-330. doi:  10.1097/MEG.0000000000000783
    [14] Wu X, Dai M, Buch H, et al. The recognition and attitudes of postgraduate medical students toward fecal microbiota transplantation: a questionnaire study[J]. Therap Adv Gastroenterol, 2019, 12: 1756284819869144.
    [15] Orduna P, Lopez SY, Schmulson M, et al. A survey using the social networks revealed poor knowledge on fecal microbiota transplantation[J]. J Neurogastroenterol Motil, 2015, 21: 294-295. doi:  10.5056/jnm14146
    [16] Ren RR, Sun G, Yang YS, et al. Chinese physicians' perceptions of fecal microbiota transplantation[J]. World J Gastroenterol, 2016, 22: 4757-4765. doi:  10.3748/wjg.v22.i19.4757
    [17] Park L, Mone A, Price JC, et al. Perceptions of fecal microbiota transplantation for Clostridium difficile infection: factors that predict acceptance[J]. Ann Gastroenterol, 2017, 30: 83-88.
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