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Volume 13 Issue 5
Sep.  2022
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Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2022  >  13(5): 858-863
MA Dongjiang, DENG Chengwu, WEI Cheng, LYU Bingzhe, WANG Chen. Characteristics of Transcription Factor POU3F2 and Its Research Progress in Tumorigenesis and Development[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 858-863. doi: 10.12290/xhyxzz.2022-0008
Citation: MA Dongjiang, DENG Chengwu, WEI Cheng, LYU Bingzhe, WANG Chen. Characteristics of Transcription Factor POU3F2 and Its Research Progress in Tumorigenesis and Development[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(5): 858-863. doi: 10.12290/xhyxzz.2022-0008
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Characteristics of Transcription Factor POU3F2 and Its Research Progress in Tumorigenesis and Development

doi: 10.12290/xhyxzz.2022-0008

  • Department of General Surgery, Lanzhou University Second Hospital, Lanzhou 730000, China

Funds:

Science and Technology Major Special Collaboration Project of Gansu Province 19ZD2WA001

More Information
  • Corresponding author: WANG Chen, E-mail: chenwang@lzu.edu.cn
  • Received Date: 2022-01-05
  • Accepted Date: 2022-02-21
    • Available Online: 2022-08-15
  • Publish Date: 2022-09-30
    Abstract
  • In recent years, with more and more basic research on the POU family, it has been found that POU domain proteins are related to cell development, replication, growth, and cell cycle blocking and differentiation. POU3F2 not only participates in embryonic development and differentiation of central neuroendocrine system, but also has wide expression in malignant tumors, and regulates the proliferation, invasion and metastasis of tumor cells in different ways to affect tumor development. Based on the structure of POU3F2, the review expounds the function and research status of POU3F2 in common malignant tumors, with the hope of further studying its mechanism and preventing diseases.
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