Email Alert RSS
Volume 13 Issue 6
Nov.  2022
Turn off MathJax
Article Contents
Article Navigation >  Medical Journal of Peking Union Medical College Hospital  > 2022  >  13(6): 1051-1056
DUAN Anqi, LUO Qin, ZHAO Zhihui, ZHAO Qing, LIU Zhihong. Right Ventricular-pulmonary Arterial Coupling in Pulmonary Hypertension: Application Advances[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 1051-1056. doi: 10.12290/xhyxzz.2021-0797
Citation: DUAN Anqi, LUO Qin, ZHAO Zhihui, ZHAO Qing, LIU Zhihong. Right Ventricular-pulmonary Arterial Coupling in Pulmonary Hypertension: Application Advances[J]. Medical Journal of Peking Union Medical College Hospital, 2022, 13(6): 1051-1056. doi: 10.12290/xhyxzz.2021-0797
shu

Right Ventricular-pulmonary Arterial Coupling in Pulmonary Hypertension: Application Advances

doi: 10.12290/xhyxzz.2021-0797

  • Center for Pulmonary Vascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, National Center for Cardiovascular Disease, Beijing 100037, China

Funds:

CAMS Innovation Fund for Medical Sciences 2020-I2M-C&T-B-055

Beijing Municipal Natural Science Foundation 7202168

More Information
  • Corresponding author: LIU Zhihong, E-mail: zhihongliufuwai@163.com
  • Received Date: 2021-12-23
  • Accepted Date: 2022-02-09
    • Available Online: 2022-11-07
  • Publish Date: 2022-11-30
    Abstract
  • Prognosis in pulmonary hypertension is closely associated with right heart function. In the early stage of pulmonary hypertension, the right ventricle can maintain the normal blood flow of the pulmonary circulation by increasing its contractility. As the disease progresses, the right ventricular afterload rises persistently, the right ventricle is gradually decompensated, even right heart failure occurs. Right ventricular-pulmonary arterial coupling refers to a matching between right ventricular contractility and afterload. The impairment of this coupling may be an early marker of right ventricular dysfunction. This article reviews the research progress of its assessment and application in pulmonary hypertension.
    • FullText(HTML)
  • loading
    • References(41)
  • [1] Simonneau G, Montani D, Celermajer DS, et al. Haemodynamic definitions and updated clinical classification of pulmonary hypertension[J]. Eur Respir J, 2019, 53: 1801913. doi:  10.1183/13993003.01913-2018
    [2] Cassady SJ, Ramani GV. Right Heart Failure in Pulmonary Hypertension[J]. Cardiol Clin, 2020, 38: 243-255. doi:  10.1016/j.ccl.2020.02.001
    [3] Campo A, Mathai SC, Le Pavec J, et al. Outcomes of hospitalisation for right heart failure in pulmonary arterial hypertension[J]. Eur Respir J, 2011, 38: 359-367. doi:  10.1183/09031936.00148310
    [4] Galiè N, Humbert M, Vachiery JL, et al. 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT)[J]. Eur Heart J, 2016, 37: 67-119. doi:  10.1093/eurheartj/ehv317
    [5] Ky B, French B, May Khan A, et al. Ventricular-arterial coupling, remodeling, and prognosis in chronic heart failure[J]. J Am Coll Cardiol, 2013, 62: 1165-1172. doi:  10.1016/j.jacc.2013.03.085
    [6] Lam CS, Shah AM, Borlaug BA, et al. Effect of antihypertensive therapy on ventricular-arterial mechanics, coupling, and efficiency[J]. Eur Heart J, 2013, 34: 676-683. doi:  10.1093/eurheartj/ehs299
    [7] Vonk-Noordegraaf A, Haddad F, Chin KM, et al. Right heart adaptation to pulmonary arterial hypertension: physiology and pathobiology[J]. J Am Coll Cardiol, 2013, 62: D22-33. doi:  10.1016/j.jacc.2013.10.027
    [8] Rosenkranz S, Howard LS, Gomberg-Maitland M, et al. Systemic Consequences of Pulmonary Hypertension and Right-Sided Heart Failure[J]. Circulation, 2020, 141: 678-693. doi:  10.1161/CIRCULATIONAHA.116.022362
    [9] Boulate D, Mercier O, Guihaire J, et al. Pulmonary Circulatory-Right Ventricular Uncoupling: New Insights Into Pulmonary Hypertension Pathophysiology. In: Maron BA, Zamanian RT, Waxman AB, editors. Pulmonary Hypertension: Basic Science to Clinical Medicine[M]. Cham: Springer International Publishing, 2016: 241-253.
    [10] Suga H, Sagawa K, Shoukas AA. Load independence of the instantaneous pressure-volume ratio of the canine left ventricle and effects of epinephrine and heart rate on the ratio[J]. Circ Res, 1973, 32: 314-322. doi:  10.1161/01.RES.32.3.314
    [11] Kubba S, Davila CD, Forfia PR. Methods for Evaluating Right Ventricular Function and Ventricular-Arterial Coupling[J]. Prog Cardiovasc Dis, 2016, 59: 42-51. doi:  10.1016/j.pcad.2016.06.001
    [12] McCabe C, White PA, Hoole SP, et al. Right ventricular dysfunction in chronic thromboembolic obstruction of the pulmonary artery: a pressure-volume study using the conduct-ance catheter[J]. J Appl Physiol (1985), 2014, 116: 355-363. doi:  10.1152/japplphysiol.01123.2013
    [13] Tedford RJ, Mudd JO, Girgis RE, et al. Right ventricular dysfunction in systemic sclerosis-associated pulmonary arterial hypertension[J]. Circ Heart Fail, 2013, 6: 953-963. doi:  10.1161/CIRCHEARTFAILURE.112.000008
    [14] Wauthy P, Pagnamenta A, Vassalli F, et al. Right ventricular adaptation to pulmonary hypertension: an interspecies comparison[J]. Am J Physiol Heart Circ Physiol, 2004, 286: H1441-H1447. doi:  10.1152/ajpheart.00640.2003
    [15] Lambert V, Capderou A, Le Bret E, et al. Right ventricular failure secondary to chronic overload in congenital heart disease: an experimental model for therapeutic innovation[J]. J Thorac Cardiovasc Surg, 2010, 139: 1197-1204. doi:  10.1016/j.jtcvs.2009.11.028
    [16] Rondelet B, Dewachter L, Kerbaul F, et al. Sildenafil added to sitaxsentan in overcirculation-induced pulmonary arterial hypertension[J]. Am J Physiol Heart Circ Physiol, 2010, 299: H1118-H1123. doi:  10.1152/ajpheart.00418.2010
    [17] Brimioulle S, Wauthy P, Ewalenko P, et al. Single-beat estimation of right ventricular end-systolic pressure-volume relationship[J]. Am J Physiol Heart Circ Physiol, 2003, 284: H1625-H1630. doi:  10.1152/ajpheart.01023.2002
    [18] Kuehne T, Yilmaz S, Steendijk P, et al. Magnetic resonance imaging analysis of right ventricular pressure-volume loops: in vivo validation and clinical application in patients with pulmonary hypertension[J]. Circulation, 2004, 110: 2010-2016. doi:  10.1161/01.CIR.0000143138.02493.DD
    [19] Siddiqui I, Rajagopal S, Brucker A, et al. Clinical and Echocardiographic Predictors of Outcomes in Patients With Pulmonary Hypertension[J]. Am J Cardiol, 2018, 122: 872-878. doi:  10.1016/j.amjcard.2018.05.019
    [20] Tello K, Wan J, Dalmer A, et al. Validation of the Tricuspid Annular Plane Systolic Excursion/Systolic Pulmonary Artery Pressure Ratio for the Assessment of Right Ventricular-Arterial Coupling in Severe Pulmonary Hypertension[J]. Circ Cardiovasc Imaging, 2019, 12: e009047. doi:  10.1161/CIRCIMAGING.119.009047
    [21] Todaro MC, Carerj S, Zito C, et al. Echocardiographic evaluation of right ventricular-arterial coupling in pulmonary hypertension[J]. Am J Cardiovasc Dis, 2020, 10: 272-283.
    [22] Rudski LG, Gargani L, Armstrong WF, et al. Stressing the Cardiopulmonary Vascular System: The Role of Echocardiography[J]. J Am Soc Echocardiogr, 2018, 31: 527-550. doi:  10.1016/j.echo.2018.01.002
    [23] Prins KW, Weir EK, Archer SL, et al. Pulmonary pulse wave transit time is associated with right ventricular-pul-monary artery coupling in pulmonary arterial hypertension[J]. Pulm Circ, 2016, 6: 576-585. doi:  10.1086/688879
    [24] Longobardo L, Suma V, Jain R, et al. Role of Two-Dimensional Speckle-Tracking Echocardiography Strain in the Assessment of Right Ventricular Systolic Function and Comparison with Conventional Parameters[J]. J Am Soc Echocardiogr, 2017, 30: 937-946. doi:  10.1016/j.echo.2017.06.016
    [25] Tanabe K, Yamaguchi K. Incorporating three-dimensional echocardiography into clinical practice[J]. J Echocardiogr, 2019, 17: 169-176. doi:  10.1007/s12574-019-00443-y
    [26] Iacoviello M, Monitillo F, Citarelli G, et al. Right ventriculo-arterial coupling assessed by two-dimensional strain: A new parameter of right ventricular function independently associated with prognosis in chronic heart failure patients[J]. Int J Cardiol, 2017, 241: 318-321. doi:  10.1016/j.ijcard.2017.04.051
    [27] Nochioka K, Querejeta Roca G, Claggett B, et al. Right Ventricular Function, Right Ventricular-Pulmonary Artery Coupling, and Heart Failure Risk in 4 US Communities: The Atherosclerosis Risk in Communities (ARIC) Study[J]. JAMA Cardiol, 2018, 3: 939-948. doi:  10.1001/jamacardio.2018.2454
    [28] Guazzi M, Bandera F, Pelissero G, et al. Tricuspid annular plane systolic excursion and pulmonary arterial systolic pressure relationship in heart failure: an index of right ventricular contractile function and prognosis[J]. Am J Physiol Heart Circ Physiol, 2013, 305: H1373-H1381. doi:  10.1152/ajpheart.00157.2013
    [29] Vriz O, Pirisi M, Bossone E, et al. Right ventricular-pulmonary arterial uncoupling in mild-to-moderate systemic hypertension[J]. J Hypertens, 2020, 38: 274-281. doi:  10.1097/HJH.0000000000002238
    [30] Lyhne MD, Kabrhel C, Giordano N, et al. The echocardiographic ratio tricuspid annular plane systolic excursion/pulmonary arterial systolic pressure predicts short-term adverse outcomes in acute pulmonary embolism[J]. Eur Heart J Cardiovasc Imaging, 2021, 22: 285-294. doi:  10.1093/ehjci/jeaa243
    [31] Trejo-Velasco B, Estevez-Loureiro R, Carrasco-Chinchilla F, et al. Prognostic Role of TAPSE to PASP Ratio in Patients Undergoing MitraClip Procedure[J]. J Clin Med, 2021, 10: 1006. doi:  10.3390/jcm10051006
    [32] Sultan I, Cardounel A, Abdelkarim I, et al. Right ventricle to pulmonary artery coupling in patients undergoing transcatheter aortic valve implantation[J]. Heart, 2019, 105: 117-121. doi:  10.1136/heartjnl-2018-313385
    [33] Colalillo A, Grimaldi MC, Vaiarello V, et al. In systemic sclerosis TAPSE/sPAP ratio can be used in addition to the DETECT algorithm for pulmonary arterial hypertension diagnosis[J]. Rheumatology (Oxford), 2021, 61: 2450-2456.
    [34] Gall H, Yogeswaran A, Fuge J, et al. Validity of echocardiographic tricuspid regurgitation gradient to screen for new definition of pulmonary hypertension[J]. Eclinical Medicine, 2021, 34: 100822. doi:  10.1016/j.eclinm.2021.100822
    [35] Gorter TM, van Veldhuisen DJ, Voors AA, et al. Right ventricular-vascular coupling in heart failure with preserved ejection fraction and pre-vs. post-capillary pulmonary hypertension[J]. Eur Heart J Cardiovasc Imaging, 2018, 19: 425-432. doi:  10.1093/ehjci/jex133
    [36] Guazzi M, Naeije R, Arena R, et al. Echocardiography of Right Ventriculoarterial Coupling Combined With Cardiopulmonary Exercise Testing to Predict Outcome in Heart Failure[J]. Chest, 2015, 148: 226-234. doi:  10.1378/chest.14-2065
    [37] Guazzi M, Dixon D, Labate V, et al. RV Contractile Function and its Coupling to Pulmonary Circulation in Heart Failure With Preserved Ejection Fraction: Stratification of Clinical Phenotypes and Outcomes[J]. JACC Cardiovasc Imaging, 2017, 10: 1211-1221. doi:  10.1016/j.jcmg.2016.12.024
    [38] Tello K, Axmann J, Ghofrani HA, et al. Relevance of the TAPSE/PASP ratio in pulmonary arterial hypertension[J]. Int J Cardiol, 2018, 266: 229-235. doi:  10.1016/j.ijcard.2018.01.053
    [39] Guo X, Lai J, Wang H, et al. Predictive value of non-invasive right ventricle to pulmonary circulation coupling in systemic lupus erythematosus patients with pulmonary arterial hypertension[J]. Eur Heart J Cardiovasc Imaging, 2021, 22: 111-118. doi:  10.1093/ehjci/jez311
    [40] Amsallem M, Sternbach JM, Adigopula S, et al. Addressing the Controversy of Estimating Pulmonary Arterial Pressure by Echocardiography[J]. J Am Soc Echocardiogr, 2016, 29: 93-102. doi:  10.1016/j.echo.2015.11.001
    [41] Ghio S, D'Alto M, Badagliacca R, et al. Prognostic relev-ance of pulmonary arterial compliance after therapy initiation or escalation in patients with pulmonary arterial hypertension[J]. Int J Cardiol, 2017, 230: 53-58. doi:  10.1016/j.ijcard.2016.12.099
    • Relative Articles(0)
    • Supplements(0)
    • Cited By
  • 加载中

Catalog

    通讯作者: 陈斌, bchen63@163.com
    • 1. 

      沈阳化工大学材料科学与工程学院 沈阳 110142

    1. 本站搜索
    2. 百度学术搜索
    3. 万方数据库搜索
    4. CNKI搜索

    Figures(1)

    Get Citation
    PDF
    XML

    Article Metrics

    Article views (384) PDF downloads(124) Cited by()
    Proportional views
    Related
    Links: National Health Commission of the People's Republic of China Chinese Academy of Medical Sciences(CAMS) AMLC Check CNKI Database CNKI Term Online Chinese General Practice
    Address：Room 302,Third Floor,Building 7, No. 1 Shuaifuyuan, Wangfujing, Dongcheng District, Beijing 100730, China
    Tel：010-69154261/4262
    E - mail：medj@pumch.cn
    mjpumch@126.com
    Copyright of website：Editorial Office of Medical Journal of Peking Union Medical College Hospital

    Supported by: Beijing Renhe Information Technology Co. Ltd    

    /

    DownLoad:  Full-Size Img  PowerPoint
    Return
    Return