Unveiling the Mystery of Long-term Repeated Multifocal-bone Swelling and Pain with Acne-like Rash

The SAPHO syndrome is a rare disease characterized by osteoarticular and dermatological manifestations. Here we reported an atypical case of SAPHO syndrome for 31 years. A multidisciplinary team made the diagnosis and differential diagnosis of the patient's osteoarticular and dermatological lesions. Subse-quently, suitable treatment was initiated and the patient's condition was significantly improved. At last, we reviewed and sum- marized the characteristics of diagnosis and treatment of SAPHO syndrome. The effectiveness and necessity of multidisciplinary treatment were demonstrated by the discussion and analysis of this rare disease.